Electroactive perovskite hydrogel suitable for electrical stimulation bone regeneration as well as preparation and application of electroactive perovskite hydrogel

A perovskite, electroactive technology, applied in the field of biomedicine, can solve the problem of neglecting bone tissue treatment, and achieve the effect of promoting calcium enrichment and osteogenic differentiation, easy availability of raw materials, good mechanical properties and compression recovery ability

Pending Publication Date: 2022-05-27
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0012] However, tissue electrical biomimetic engineering is mainly used in the treatment of traditional excitable tissues such as nerves and cardiovascular tissues, while ignoring the treatment of bone tissue that also has bioelectric properties. Early restoration of normal bone electrical activity may be the key rate-limiting bone formation. step

Method used

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  • Electroactive perovskite hydrogel suitable for electrical stimulation bone regeneration as well as preparation and application of electroactive perovskite hydrogel
  • Electroactive perovskite hydrogel suitable for electrical stimulation bone regeneration as well as preparation and application of electroactive perovskite hydrogel
  • Electroactive perovskite hydrogel suitable for electrical stimulation bone regeneration as well as preparation and application of electroactive perovskite hydrogel

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Embodiment 1

[0046] (1) Dissolve sodium alginate powder in deionized water, adjust to weak alkaline solution (pH=8.0) with sodium hydroxide solution, slowly add methacrylic anhydride solution dropwise, and stir at 4° C. for 24 hours to react to obtain a connection The sodium alginate solution A of branch methacrylic acid, the final concentration of sodium alginate in the solution A is 10mg / mL, and the final concentration of methacrylic anhydride is 5vol%;

[0047] (2) Dialyzing and drying solution A to obtain sodium alginate powder, dissolved in deionized water to obtain purified solution B, and the concentration of purified sodium methacrylate alginate in solution B is 20 mg / mL;

[0048](3) add calcium phosphate, magnesium titanate and poly(3,4-ethylenedioxythiophene) to solution B: poly(styrene sulfonate), stir to obtain solution C; the calcium phosphate concentration in solution C is 10 mg / mL, the perovskite concentration is 10 mg / mL, and the poly(3,4-ethylenedioxythiophene): poly(styre...

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Abstract

The invention discloses an electroactive perovskite hydrogel suitable for electrical stimulation bone regeneration, a preparation method of the electroactive perovskite hydrogel and application of the electroactive perovskite hydrogel in preparation of drugs and stents for repairing bone defects. The preparation method comprises the following steps: dissolving sodium alginate powder in deionized water, adjusting the pH value to 7.4-8.0 by using a sodium hydroxide solution, dropwise adding a methacrylic anhydride solution, and stirring for reaction to obtain a methacrylic acid grafted sodium alginate solution marked as a solution A; dialyzing and drying the solution A to obtain methacrylic acid sodium alginate powder, and dissolving the methacrylic acid sodium alginate powder in deionized water to obtain a purified solution B; adding calcium phosphate, perovskite and poly (3, 4-ethylenedioxythiophene): poly (styrene sulfonate) into the solution B, and uniformly stirring to obtain a solution C; and dissolving a photoinitiator in the solution C, and carrying out a cross-linking reaction under ultraviolet irradiation to obtain the electroactive perovskite hydrogel suitable for electrical stimulation bone regeneration.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to an electroactive perovskite hydrogel suitable for electrically stimulating bone regeneration and a preparation method and application thereof. Background technique [0002] Bone is a hard tissue in vertebrates, mainly composed of hydroxyapatite and collagen fibers. Once the bone structure in the organism is damaged, it will cause a series of diseases, such as fractures, osteoporosis, osteoarthritis and bone defects. [0003] At present, bone injury has become an increasingly serious health problem, posing a huge threat to human health. [0004] Therefore, the effective prevention and treatment of orthopedic-related diseases has become a key problem that needs to be solved urgently in contemporary society. [0005] Although both autologous bone and allogeneic bone graft can be used for bone defect repair, their single structure or high cost limit their clinical application. ...

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Application Information

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IPC IPC(8): C08J3/075C08J3/24C08J3/28C08L5/04C08L25/18C08L65/00A61L27/02A61L27/16A61L27/18A61L27/20A61L27/50A61L27/52A61N1/04
CPCC08J3/075C08J3/246C08J3/28A61L27/52A61L27/50A61L27/025A61L27/20A61L27/16A61L27/18A61N1/0496A61L2430/02C08J2305/04C08J2425/18C08J2465/00C08L5/04C08L25/18C08L65/00Y02E10/549
Inventor 姚沙沙余聪聪唐睿康范顺武
Owner ZHEJIANG UNIV
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