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Application of composition in preparation of medicine

A composition and application technology, applied in the field of medicine, can solve the problems of blindness, vision loss, patient burden and the like

Active Publication Date: 2022-06-07
XIAN BEILIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, choroidal neovascularization is a very difficult disease, which often causes severe vision loss and even blindness, seriously affects the quality of life and work ability of patients, and brings a heavy burden to patients, their families and society.
Surgery and laser therapy have been shown to be ineffective, so current treatments targeting choroidal neovascularization remain to be investigated

Method used

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  • Application of composition in preparation of medicine
  • Application of composition in preparation of medicine
  • Application of composition in preparation of medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Preparation of tablets

[0027] Recipe: Puhuang 75g, Salvia 75g, Rehmannia glutinosa 60g, Eclipta 60g, Chrysanthemum 50g, Scutellaria baicalensis (charcoal) 45g, Cassia 45g, Plantain 45g, Cinnamon 45g, Ligustrum lucidum 45g, Prunella 45g, Gentian 45g, turmeric 30g, equisetum 45g, red peony root 30g, peony bark 30g, hawthorn 30g, angelica 30g, chuanxiong 10g.

[0028] The process steps are as follows:

[0029] (1), fry Scutellaria baicalensis into a charcoal shape with a strong fire, for subsequent use;

[0030] (2), the Scutellaria baicalensis prepared in the step (1) of 50g chrysanthemum, 45g, 22.5g psyllium and 37.5g Puhuang are mixed and pulverized into 80-120 mesh fine powder, for subsequent use;

[0031] (3), the remaining 22.5g of psyllium, 37.5g of Puhuang and the remaining 15 Chinese medicines were soaked in water for 30 minutes, decocted twice, every 2 hours, merged the decoction, filtered;

[0032] (4), concentrating the filtrate under reduced pr...

Embodiment 2

[0033] Example 2: Preparation of capsules

[0034] Recipe: Puhuang 65g, Salvia 65g, Rehmannia glutinosa 50g, Eclipta 50g, Chrysanthemum 40g, Scutellaria baicalensis 35g, Cassia 35g, Plantain 35g, Cinnamon 35g, Ligustrum lucidum 35g, Prunella vulgaris 35g, Gentian 35g, Gold 20g, Equisetum 35g, Chishao 20g, Cortex Moutan 20g, Hawthorn 20g, Angelica 20g, Chuanxiong 5g.

[0035] The process steps are as follows:

[0036] (1), fry Scutellaria baicalensis into a charcoal shape with a strong fire, for subsequent use;

[0037](2), the Scutellaria baicalensis prepared in the step (1) of 40g chrysanthemum, 35g, 17.5g plantain seeds and 32.5g Puhuang are mixed and pulverized into 80-120 mesh fine powder, for subsequent use;

[0038] (3), the remaining 17.5g of psyllium, 32.5g of Puhuang and the remaining 15 Chinese medicines were soaked in water for 30 minutes, decocted twice, each 2 hours, merged the decoction, and filtered;

[0039] (4), concentrating the filtrate under reduced pres...

Embodiment 3

[0040] Example 3: Preparation of Granules

[0041] Recipe: Puhuang 80g, Salvia 80g, Rehmannia glutinosa 70g, Eclipta 70g, Chrysanthemum 60g, Scutellaria baicalensis 50g, Cassia 50g, Plantain 50g, Cinnamon 50g, Ligustrum lucidum 50g, Prunella vulgaris 50g, Gentian 50g, Gold 40g, Equisetum 50g, Red Peony 40g, Cortex Moutan 40g, Hawthorn 40g, Angelica 40g and Chuanxiong 15g.

[0042] The process steps are as follows:

[0043] (1), fry Scutellaria baicalensis into a charcoal shape with a strong fire, for subsequent use;

[0044] (2), mix chrysanthemum, skullcap, half amount of psyllium, half amount of Puhuang, mix and pulverize into 80-120 mesh fine powder, for use;

[0045] (3), the remaining psyllium, Puhuang and the remaining 15 Chinese medicines were soaked in water for 30 minutes, decocted twice, each time for 2 hours, merged the decoction, and filtered;

[0046] (4), concentrating the filtrate under reduced pressure to a thick paste with a temperature of 60° C. and a rela...

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Abstract

The invention provides application of a composition in preparation of a medicine for treating high expression diseases of a VEGF (vascular endothelial growth factor) gene or an FGF-2 (fibroblast growth factor 2) gene, and the composition is used for inhibiting expression of the VEGF gene or the FGF-2 gene. The composition is prepared from pollen typhae, radix salviae miltiorrhizae, radix rehmanniae, herba ecliptae, flos chrysanthemi, radix scutellariae, semen cassiae, semen plantaginis, fructus leonuri, fructus ligustri lucidi, spica prunellae, radix gentianae, radix curcumae, herba equiseti hiemalis, radix paeoniae rubra, cortex moutan, fructus crataegi, radix angelicae sinensis and rhizoma chuanxiong. Therefore, a scientific research and clinical application foundation is laid for high-expression diseases of the VEGF gene or the FGF-2 gene.

Description

technical field [0001] The present invention relates to the field of medicine. In particular, the present invention relates to the use of the composition in the manufacture of a medicament. Background technique [0002] Neovascularization is stimulated and regulated by a variety of factors, among which the most important and widely studied is the VEGF family. The protein encoded by the FGF-2 gene is a member of the fibroblast growth factor family. FGF family members bind heparin and have broad mitogenic and angiogenic activities. Since the advent of anti-VEGF drugs more than ten years ago, they have been widely used in clinics as first-line drugs for the treatment of ocular neovascularization. However, there are still some patients with ocular neovascularization whose treatment effect is not good, and it often needs to be repeated on a monthly basis. The second treatment not only brings an economic burden to the patient, but also increases the risk of serious complication...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P9/10A61P27/02
CPCA61K36/88A61K36/537A61K36/804A61K36/28A61K36/287A61K36/539A61K36/482A61K36/68A61K36/533A61K36/638A61K36/536A61K36/515A61K36/9066A61K36/11A61K36/71A61K36/65A61K36/734A61K36/232A61K36/236A61P9/10A61P27/02A61K2300/00
Inventor 苗彦孙瑞鸿
Owner XIAN BEILIN PHARMA
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