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Electrotransfer therapy delivery devices, systems, and methods

A technology of electrotransfer and electrodes, applied in the direction of electrotherapy, biochemical equipment and methods, treatment, etc., which can solve the problems that limit the accessibility of such treatments

Pending Publication Date: 2022-07-29
NEWSOUTH INNOVATIONS PTY LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This may limit the availability of such therapies

Method used

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  • Electrotransfer therapy delivery devices, systems, and methods
  • Electrotransfer therapy delivery devices, systems, and methods
  • Electrotransfer therapy delivery devices, systems, and methods

Examples

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Embodiment Construction

[0066] One aspect disclosed herein is a device capable of efficient electrical transfer of DNA into cells through a single capacitive discharge.

[0067] The principle of this system involves storing charge quanta on a capacitor, which is then discharged through an array of electrodes configured to generate an electric field having an electric field potential gradient focused on an area by the array configuration and of sufficient strength to DNA is efficiently electrotransferred into cells. This DNA or related ribonucleic acid molecules or even other charged molecules can affect changes in biological function once they enter the cell.

[0068] In some embodiments, this may be the discharge of a single capacitor.

[0069] figure 1 An example of an electrotransfer system 100 with at least one probe 110 and a charging station 120 is shown. Each probe 110 includes a probe body 170 , a needle electrode array 130 and a discharge circuit 145 . In the simplest embodiment, the dis...

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Abstract

Disclosed is a device capable of efficiently electrotransferring DNA into cells by means of single-capacitance discharge. The principles of the system involve storing charge quanta on a capacitor and then discharging it through an array of electrodes configured to generate an electric field having an electric field potential gradient focused to a region through an array configuration and having an intensity sufficient to efficiently electrically transfer DNA into cells. The DNA or associated ribonucleic acid molecules or even other charged molecules, once entering the cell, affect the change in biological function.

Description

technical field [0001] The field of the invention is electric field stimulated transfection of cells to deliver therapeutic molecules, particularly using linear electrode arrays on a single probe. One application of the present invention is for electrotransfer of DNA into cells. Background technique [0002] Electric field-stimulated cell transfection or electrotransfer for delivery of therapeutic agents to cells is commonly referred to as electroporation. Electroporation is typically accomplished by injecting the tissue with a therapeutic agent (eg, a solution of therapeutic molecules) and inserting two separate probes into the tissue on either side of the target treatment area, one serving as the cathode and the other as the anode , and pass current through the tissue between the two probes. This causes temporary damage to the cell membrane, allowing the penetration of the therapeutic agent into the cell, also known as transfection. This is a known method for delivering...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/30A61N1/04
CPCA61N1/0502A61N1/0541C12N15/87A61K48/00C12M35/02C12N13/00A61M2005/2006A61N1/327A61N1/0412A01K67/0275A01K2207/05C12N15/64
Inventor G·D·郝斯利J·宾勇N·H·洛弗尔E·N·克劳福德A·艾尔阿贝德G·冯容凯尔
Owner NEWSOUTH INNOVATIONS PTY LTD
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