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Traditional Chinese medicine composition for treating arrhythmia and preparation method thereof

A technology for arrhythmia and a composition, which is applied in the field of natural active medicine for arrhythmia and its preparation, can solve the problems of health hazards of patients with chronic arrhythmia, deterioration of cardiac function of patients, unsuitability of patients, etc., and achieves improvement of neurohumoral hormone levels, Shortening the RR interval and having a significant effect

Active Publication Date: 2022-08-05
XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As an effective strategy for the treatment of BA, pacemaker implantation is not only expensive, but also requires life-long follow-up, which affects the quality of life of patients to varying degrees, and the incidence of complications of pacemaker implantation continues to increase. Implantation of permanent pacemakers is prone to complications such as electrode dislocation, pocket hematoma or infection symptoms, hemopneumothorax, pacing syndrome, etc., which will seriously endanger the health of patients with chronic arrhythmia. There is a possibility of new-onset atrial fibrillation after surgery, which can lead to the deterioration of the patient's heart function, so some patients are not suitable or refuse to accept this kind of treatment

Method used

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  • Traditional Chinese medicine composition for treating arrhythmia and preparation method thereof
  • Traditional Chinese medicine composition for treating arrhythmia and preparation method thereof
  • Traditional Chinese medicine composition for treating arrhythmia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0186] Example 1 The present invention Wen Yanghuixuemu Granules Preparation

[0187] 1) According to the following ratio, the raw material (unit: × 10g)

[0188] Yanhu Mo 15, Gao Liangjiang 12, 荜茇 10, cinnamon 6, dry ginger 6, honey ephedra 3, cinnamon 6, tulip 12, Danshen 10, red peony 10, prince 12, astragalus 12, astragalus 12, astragalus 12, astragalus 12, astragalus 12

[0189] 2) Put the medicinal materials Yanhu, Gao Liang ginger, 荜茇, cinnamon, dried ginger, honey ephedra, cinnamon, tulip, Danshen, Chi Zhi, Prince Ginseng, astragalus, and place it in a multi -function extraction tank in Chinese medicine, add tap water and soak 60min, the ratio of the weight (dry weight) of the tap water and the weight of the medicinal material is 12: 1;

[0190] 3) Turn on the multi -function extraction can of the power supply for heating, heat to 100 ° C, and keep the constant temperature return extraction at this temperature for 1 hour, and get the first extraction solution. The temperat...

Embodiment 2

[0194] Example 2 Preparation of Win Yanghuixuemu Founding Dose for the invention 2

[0195] 1) According to the following ratio, the raw material (unit: × 10g)

[0196] Yanhu Mo 12, Gao Liang Jiang 12, 荜茇 12, Cinnamon 6, Dry Ginger 10, Honey Ephedra 3, Guizhi 6, Tulip 15, Danshen 12, Chi Ri 10, Prince Ginseng 10, astragalus 20, astragalus 20

[0197] 2) Put the medicinal materials Yanhu, Gao Liang ginger, 荜茇, cinnamon, dried ginger, honey ephedra, cinnamon, tulip, Danshen, Chi Zhi, Prince Ginseng, astragalus, and place it in a multi -function extraction tank in Chinese medicine, add tap water and soak 45min, the ratio of the weight (dry weight) of the tap water and the weight of the medicinal material is 10: 1;

[0198] 3) Turn on the multi -function extraction can of the power supply for heating, heat it to 100 ° C, and keep the constant temperature extraction at this temperature for 2 hours, and get the first extraction solution; add tap water to the filter residue, heat extract...

Embodiment 3

[0202] Example 3 Preparation of the invention Wenyang Huixiu Fang Capsule

[0203] 1) Prepare raw materials (× 10g) according to the following weight ratio:

[0204] Yanhu Mo 15, Gao Liangjiang 15, 荜茇 10, cinnamon 10, dry ginger 6, honey ephedra 6, cinnamon 10, tulip 12, Danshen 10, red peony 12, prince 20, astragalus 10, astragalus 10

[0205] 2) Put the medicinal materials Yanhu, Gao Liang ginger, 荜茇, cinnamon, dried ginger, honey ephedra, cinnamon, tulip, Danshen, Chi Zhi, Prince Ginseng, astragalus, and place it in a multi -function extraction tank in Chinese medicine, add tap water and soak 30 minutes, the ratio of the weight (dry weight) of the added tap water to the weight of the medicinal material is 9: 1;

[0206] 3)开启多功能提取罐电源进行加热,加热至100℃,保持在此温度下恒温提取1.5小时后过滤,得到第一次提取液;向滤渣中分2次加入自来水,加热提取2次,每The temperature extracted temperature is 100 ° C. The weight of the total weight of the tap water added to the total weight of the medicinal material is 9: 1, the extraction time is 1.5 h...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic arrhythmia and a preparation method of the traditional Chinese medicine composition. The composition is prepared from rhizoma corydalis, rhizoma galangae, fructus piperis longi, cortex cinnamomi, rhizoma zingiberis, herba ephedrae, ramulus cinnamomi, radix curcumae, radix salviae miltiorrhizae, radix paeoniae rubra, radix pseudostellariae and radix astragali seu hedysari. The composition for treating chronic arrhythmia, especially chronic arrhythmia, can be prepared into any common oral dosage form. The traditional Chinese medicine composition disclosed by the invention has the effects of warming yang, activating blood, tonifying qi and promoting coronary circulation, and obviously improves the minimum heart rate and the total heart beat number; the RR interval is obviously shortened, the arrest number larger than 2s within 24 hours is reduced, and the SNRT and SACT time is shortened; the protein expressions of HCN4, SCN5A, KCNH2 and CRH in the sinus atrioatrial node region are up-regulated, and the protein expression of CHRM2 in the sinus atrioatrial node region is down-regulated, so that the treatment on bradyarrhythmia is remarkably improved; the medicine is obvious in effect, convenient to take and free of toxic and side effects.

Description

Technical field [0001] The present invention involves a drug and its preparation method for cardiovascular diseases, and specially involves a natural active drug and its preparation methods with arrhythmia. Background technique [0002] Subsidal arrhythmia (Bradycardiac Arrhythmia (BA) is a type of cardiovascular disease that is characterized by slow heart rate and can be accompanied by hemodynamic disorders. Obstacles and life. According to its onset part, BA caused by ① sinus node and surrounding tissue lesions, ② BA caused by room conduction block, ③ indoor conduction blocks caused by ba. The causes of the disease are divided into two types: heart -based and non -heartbonic. How good the child and adolescent heart source BA will occur in the first heart disease, myocarditis, etc. The degenerative lesions of the conduction system developed. Non -heart source BA is more common in autonomic nerve disorders and hypothyroidism. [0003] BA -free people generally do not need to be t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P9/06
CPCA61K36/66A61K36/9062A61K36/67A61K36/54A61K36/9068A61K36/17A61K36/9066A61K36/537A61K36/71A61K36/65A61K36/36A61K36/481A61P9/06A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 翁维良李秋艳张菀桐任建勋王旭杰
Owner XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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