Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Protein methylation site prediction method, device and equipment

A technology of methylation sites and prediction methods, applied in the field of protein methylation site prediction, can solve problems such as poor stability and low accuracy

Pending Publication Date: 2022-08-09
SHENZHEN UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods are all based on the one-dimensional structure of the protein, that is, the protein sequence to predict the methylation site, which has poor stability and low accuracy.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Protein methylation site prediction method, device and equipment
  • Protein methylation site prediction method, device and equipment
  • Protein methylation site prediction method, device and equipment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0055] In the following description, for the purpose of illustration rather than limitation, specific details, such as specific system structures and technologies, are provided for a thorough understanding of the embodiments of the present application. However, it will be apparent to those skilled in the art that the present application may be practiced in other embodiments without these specific details. In other instances, detailed descriptions of well-known systems, devices, circuits, and methods are omitted so as not to obscure the description of the present application with unnecessary detail.

[0056] It should be understood that, as used in this specification and the appended claims, the term "and / or" refers to and including any and all possible combinations of one or more of the associated listed items. In addition, in the description of the specification of the present application and the appended claims, the terms "first", "second", "third", etc. are only used to dis...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a protein methylation site prediction method, device and equipment, relates to the technical field of biological information, can more accurately predict a protein methylation site, and is high in robustness. The method comprises the following steps: acquiring three-dimensional structure data of a to-be-detected protein, wherein the protein consists of a plurality of amino acids; according to the three-dimensional structure data, a graph structure with amino acids as nodes is constructed, and each node in the graph structure corresponds to one amino acid; according to preset parameters, sub-graphs are extracted from the graph structure, and the preset parameters comprise a sub-graph hop count and a distance threshold value; and inputting the sub-graph into the trained graph convolutional neural network for methylation site prediction.

Description

technical field [0001] The present application relates to the technical field of biological information, and in particular, to a method, device and equipment for predicting protein methylation sites. Background technique [0002] Methylation is an important modification of proteins and nucleic acids. It regulates the expression and shutdown of genes. It is closely related to many diseases such as cancer, aging, and Alzheimer's. It is one of the important research contents of epigenetics. The most common methylation modifications are DNA methylation and histone methylation. Methylation refers to the process of catalytically transferring methyl groups from active methyl compounds to other compounds, which can form various methyl compounds, or chemically modify certain proteins or nucleic acids to form methylated products. [0003] Methylation of proteins occurs mainly at lysine and arginine. At present, most of the researches on predicting protein methylation sites use tradi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G16B40/00G16B30/00G16B15/20
CPCG16B40/00G16B30/00G16B15/20
Inventor 陈杰李坚强顾凌嫣陈廷柏梁中明
Owner SHENZHEN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com