Method for producing 2,4,5-trialkyl-benzaldehyde
A technology for trialkylbenzene and formaldehyde, which is used in the production field of 2,4,5-trialkylbenzaldehyde
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Embodiment 1
[0024] Add 6.7 grams of 1,2,4-trimethylbenzene into a 100 mL autoclave, and then slowly add 50 grams of trifluoromethanesulfonic acid. After purging with carbon monoxide, the reaction was carried out at a carbon monoxide partial pressure of 5 MPa and 0° C. for 90 minutes. After the reaction, the reaction compound was poured into ice water, and then the product was extracted with ether. The ether solution thus obtained was analyzed by gas chromatography. The results of the analysis showed the formation of 2,4,5-trimethylbenzaldehyde in a 93% yield on a molar basis. The selectivity of 2,4,5-trimethylbenzaldehyde over converted 1,2,4-trimethylbenzene was 98%.
[0025] From the analysis results of GC and NMR, it can be seen that neither positional isomers nor by-products produced by the disproportionation reaction were detected. Although there were two trace by-product peaks, mass spectral analysis revealed that these were high molecular species, presumed to be dimers and trimers...
Embodiment 2-11
[0027] The reaction of Example 1 was carried out with the reaction temperature, the ratio of trifluoromethanesulfonic acid to 1,2,4-trimethylbenzene, the pressure of carbon monoxide, the reaction time and the stirring rate respectively changed as shown in Table 1. The results are listed in Table 1.
[0028] The values in Table 1 are calculated by the following formula:
[0029] Catalyst / substrate=[the amount of added trifluoromethanesulfonic acid (in moles)] / [the amount of added 1,2,4-trimethylbenzene (in moles)]
[0030] Conversion ratio=[the amount of 1,2,4-trimethylbenzene reacted (in moles)] / [the amount of 1,2,4-trimethylbenzene added (in moles)]×100
[0031] Yield=[the amount of 2,4,5-trimethylbenzaldehyde generated (in moles)] / [the amount of 1,2,4-trimethylbenzene added (in moles)]×100
[0032] Selectivity=[the amount of 2,4,5-trimethylbenzaldehyde (in moles)] / [the amount of 1,2,4-trimethylbenzene reacted (in moles)]×100
[0033] Example
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