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Heat-resisting lyophilized protectant for swine fever lapinized hyoptoxicity calf testicular cell vaccine and preparing process

A technology of heat-resistant freeze-drying and protective agents, which can be applied in the direction of antiviral agents, medical preparations containing active ingredients, antibody medical ingredients, etc., and can solve problems such as no detailed reports on methods

Inactive Publication Date: 2005-07-20
卫广森
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no detailed report on the method

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0008] The heat-resistant freeze-drying protectant of swine fever rabbit-type attenuated calf testicular cell seedlings includes commonly used gelatin and lactose, and is characterized in that the material composition weight percentage of the heat-resistant freeze-dry protectant is: gelatin 3%, lactose 5-6% , beef peptone 2%, PVP (K90) 3%, sorbitol 2%, sodium glutamate 2%, Vc 0.1%; in the preparation, it is a dry matter component, and the rest of the percentage is distilled water.

[0009] The preparation process of the heat-resistant freeze-drying protective agent for the hog-rabbitized attenuated calf testicular cell seedlings includes mixing the dry matter components of the above-mentioned heat-resistant freeze-drying protective agent in proportions by weight, and the feature is that the effective composition of the protective agent is Sterilize each part: (1) Dissolve the autoclavable substances: gelatin, lactose, PVP (K90), beef peptone in distilled water according to thei...

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Abstract

The present invention relates to a heat-resisting freeze-dried protection agent for hog cholera lapinized low virulent strain calf testis cell vaccine and its preparation method. The composition of said protection agent includes gelatin 3%, lactose 5-6%, beef peptone 2%, PVP (K90)3%, sorbitol 2%, sodium glutamate 2% and Vc 0.1%, and in the preparation they are dried substance components, and the rest is distilled water. The above-mentioned composition comprises two portions, one portion of them can be sterilized at high pressure, and another portion is not resistant to high temperature, and can be sterilized by using filtration membrane, said two portions after which are respectively sterilized are mixed.

Description

technical field [0001] The invention relates to a freeze-drying technology of biological products, a preservation auxiliary agent and a manufacturing method thereof. Background technique [0002] The commonly used protective agents for veterinary biological products in my country are mainly 5% sucrose skimmed milk, 5-10% sucrose, and 1.5-3% gelatin. -9 months, must be used up as soon as possible at room temperature. This brings many difficulties and inconveniences to the preservation, transportation, use, etc. of veterinary biological products. At the same time, energy consumption and storage costs are high due to the necessity of low-temperature preservation. [0003] At present, almost all veterinary biological freeze-dried products in developed countries in the world are stored at 2-8°C for more than 24 months. But there is no detailed report on the method. Chinese patent CN1176827A "A Manufacturing Method for Freeze-dried Live Vaccines for Animals" proposes to use poly...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/187A61P31/12
Inventor 卫广森王文成张万林
Owner 卫广森