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Use of 2a, 23-dihydroxyl ursolic acid in preparing the anti-inflammatory agent

A technology of dihydroxyursolic acid and anti-inflammatory drugs, applied in the field of medicine, can solve the problems of no clinical application and no anti-inflammatory effect

Inactive Publication Date: 2005-08-24
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the treatment of diseases, let alone the report of anti-inflammatory effect, and it has not been applied clinically

Method used

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  • Use of 2a, 23-dihydroxyl ursolic acid in preparing the anti-inflammatory agent
  • Use of 2a, 23-dihydroxyl ursolic acid in preparing the anti-inflammatory agent
  • Use of 2a, 23-dihydroxyl ursolic acid in preparing the anti-inflammatory agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Local anti-inflammatory effect of DHUA on TPA-induced acute ear swelling in mice

[0018] The ICR mice were randomly divided into blank group (acetone), TPA group, positive control group (indomethacin) and administration group. Both sides of the mouse's right ear were coated with inflammatory solution [containing 10% (g·mL -1 )TPA (phorbol ester) / acetone] 10 μl, DHUA was dissolved in an equal volume of acetone, and the same part was applied immediately after TPA was applied to the mouse ear. After 6 hours, the animals were sacrificed by cervical dislocation, and ear tissues (diameter 6 mm) were obtained from the same part of the right ear with a punch. weight 给药组 -Ear piece weight 丙酮组 ) / (Ear piece weight TPA组 -Ear piece weight 丙酮组 )]} × 100%.

[0019] Table 1 Local anti-inflammatory effect of terminalia leaf extract on TPA-induced acute ear swelling in mice

[0020] Group Dose Ear piece weight a I.R. b

[0021] (mg / ear) (mg) ...

Embodiment 2

[0029] Anti-inflammatory effect of DHUA on TPA-induced chronic ear inflammation in mice

[0030] The ICR mice were randomly divided into TPA group, positive control group (dexamethasone 0.05 mg / ear) and administration group [DHUA (0.3 mg / ear)]. Both sides of the mouse's right ear were coated with inflammatory solution [containing 10% (g·mL -1 )TPA (phorbol ester) / acetone] 10μl, and then apply the drug to the same part immediately, twice a day, with an interval of 6h, for three consecutive days, and once on the fourth day. After 6 hours, the animals were sacrificed by cervical dislocation, and ear tissues (diameter 6 mm) were obtained from the same part of the right ear with a punch. weight 给药组 -Ear piece weight 丙酮组 ) / (Ear piece weight TPA组 -Ear piece weight 丙酮组 )]} × 100%. see results figure 1 .

[0031] Another ear piece sample was taken and stored in HTAB for myeloperoxidase testing. Myeloperoxidase (MPO) activity detection: put the ear piece sample in 0.75ml PBS (8...

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PUM

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Abstract

The invention relates to the field of natural medicament, in particular, the invention discloses the novel use of 2 alpha, 23-dihydroxy ursolic acid in preparing anti-inflammatory medicines.

Description

[0001] Technical Field The present invention relates to the field of medicine, and discloses a new medical application of 2α, 23-dihydroxyursolic acid, that is, the application for preparing anti-inflammatory drugs. Background technique [0002] The full name of 2α, 23-dihydroxyursolic acid is 2α, 3β, 23-trihydroxyursane-28-acid, commonly known as 2α, 23-dihydroxyursolic acid, and its English name is 2α, 3β, 23-trihydroxyurs-12 -en-28-oic acid (DHUA for short), with the following structural formula, is an active ingredient present in Terminalia, Centella asiatica, Rhoccloclenclron japonicum and other plants. There is no report of being used for treating diseases, and no report of anti-inflammatory effect, nor clinical application. [0003] [0004] R 1 R 2 [0005] ursolic acid (UA) (ursolic acid) H CH 3 [0006] 2α, 3β, 23-trihydroxyurs-12-en-28-oic acid (DHUA) (2α, 23-dihydroxyursolic acid) O...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/56A61P29/00
Inventor 范怡梅高静徐力致赵晓宁王勇汤新慧杨晓荷窦环王燕萍朱俐
Owner NANJING UNIV