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Medicine composition for preventing and treating asthma and chronic bronchitis and its preparation process

A composition and drug technology, applied in the field of medicine, can solve the problems of not being able to be used alone for asthma patients, narrow anti-inflammatory spectrum, application effect and safety evaluation, etc.

Inactive Publication Date: 2006-06-21
吴红梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, leukotriene receptor antagonists only act on the inflammatory mediator leukotrienes, and their anti-inflammatory spectrum is relatively narrow, so they cannot completely replace the anti-inflammatory effect of hormones
From the perspective of economy and curative effect, leukotriene receptor antagonists cannot become the main single drug for asthmatic patients in my country at present, and their main therapeutic value may lie in the combined application with GC in the treatment of moderate and severe asthma.
[0009] In recent years, certain anticholinergic drugs, calcium ion antagonists, potassium ion channel activators, immunomodulators, cytokine regulators, and antiallergic drugs have shown certain preventive and therapeutic effects on asthma, but long-term application effects and safety still need to be solved. further evaluation
[0010] It can be seen that in recent years, the treatment of western medicine is not very satisfactory, and there is still a lack of drugs that can eliminate chronic inflammation with good long-term curative effect, low price and small side effects.

Method used

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  • Medicine composition for preventing and treating asthma and chronic bronchitis and its preparation process
  • Medicine composition for preventing and treating asthma and chronic bronchitis and its preparation process
  • Medicine composition for preventing and treating asthma and chronic bronchitis and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Embodiment 1: the extraction example of pharmaceutical composition in the present invention

[0072] Epimedium and Fructus Cnidii are properly crushed, mixed thoroughly at a ratio of 2:1, a total of 1000g, extracted twice with 70% ethanol (10 times the amount, 1.5h; 8 times the amount, 1h); , concentrated under reduced pressure, and then centrifuged to remove the precipitate; after the solvent was recovered under reduced pressure, an appropriate amount of water was added, and the sample was suspended by ultrasonic treatment. On the sample liquid (pretreatment has been completed) macroporous adsorption resin AB-8, the amount of resin is 500g, the impurities that are not adsorbed are washed with water, and then eluted with 70% ethanol; the collected liquid is concentrated, spray-dried to obtain the 34.29g of dry powder with total flavonoids of Husk and total coumarin of Cnidium as the main active ingredients, the yield is 3.43%.

Embodiment 2

[0073] Embodiment 2: Determination of content of icariin, total flavonoids of Epimedium, osthole, total coumarin of Cnidium

[0074] 2.1. Both icariin and osthole were purchased from China National Institute for the Control of Pharmaceutical and Biological Products, and both were used as reference substances for purification research and content determination.

[0075] 2.2. The content of icariin, total flavonoids of Epimedium, and osthole were determined according to the provisions of the content determination item of Chinese medicinal materials in the Pharmacopoeia of the People's Republic of China in 2000, respectively, using high-performance liquid chromatography, ultraviolet-visible Spectrophotometry, thin-layer scanning chromatography. In Example 1, icariin is 18.42%, total flavonoids of Epimedium is 41.1%, and osthole is 7.3%.

[0076] 2.3. Determination of the total coumarin content of Cnidium Fructus refers to the literature [Zhang Xinyong, Xiang Rende, Zhang Genyuan...

Embodiment 3

[0077] Embodiment 3: the influence of the present invention on guinea pig allergic asthma

[0078]3.1 Materials and methods

[0079] 3.1.1 Animal grouping: 60 hartley guinea pigs, weighing 230±20g, were randomly divided into A model control group, B dexamethasone group, and C epimedium total flavonoids (provided by the Analytical Chemistry Laboratory of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, content 62.1%) , yield is 2.35%.) group, D Cnidium total coumarin (provided by Shanghai University of Traditional Chinese Medicine Analytical Chemistry Office of Chinese Medicine, content 57.4%, yield is 1.84%.) group, E Epimedium, snakehead of the present invention Fructus Cnidii composition (provided by the Laboratory of Analytical Chemistry of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, the ratio of Epimedium and Fructus Cnidii is 2:1, decocted in 10 times the amount of water, 1 hour each time, twice in total, and the filtrate i...

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Abstract

The invention relates to a pharmaceutical composition for preventing and treating asthma and chronic bronchitis which is composed of Chinese medicinal materials Epimedium, Cnidium or their extracts, and obtains mainly containing total flavonoids of Epimedium and total coumarin of Cnidium, etc. The preparation process of the pharmaceutical composition of the active ingredient; the present invention also relates to the application of the pharmaceutical composition in the prevention and treatment of bronchial asthma, chronic bronchitis and chronic obstructive pulmonary disease.

Description

Technical field: [0001] The invention relates to the field of medicine, in particular to traditional Chinese medicines Epimedium and Cnidium, in particular to a pharmaceutical composition containing Epimedium extract and Cnidium extract for preventing and treating asthma and chronic bronchitis and a preparation process thereof. Background technique: [0002] Bronchial asthma (asthma for short) is a common disease and a frequently-occurring disease that seriously threatens people's health worldwide. Asthma, Germany has 4 million asthma patients, Japan has 3 million, Western Europe has doubled in the past ten years, and the United States has increased by 60% compared with the early 1980s; the number of people dying from asthma in the world is as high as 180,000 every year. The prevalence of asthma in my country is about 0.5% to 2.0% according to the survey in some areas, and it is also reported as high as 5.29%. There are 10 million to 20 million patients in the country, mostl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/296A61K36/234A61K131/00A61P11/06A61P11/00
Inventor 吴红梅吴银根孟志强
Owner 吴红梅
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