Skin-lightening cosmetic

A technology of whitening cosmetics and protein, which is applied in the field of whitening cosmetics and can solve problems such as poor stability of cosmetics

Inactive Publication Date: 2000-09-13
SUNSTAR KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the stability of cosmetics related to this is not very good, and it is found that the concentration of linoleic acid must be more than 1% by weight when it works, and it is difficult to say that it shows a sufficient effect at a low concentration.

Method used

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  • Skin-lightening cosmetic
  • Skin-lightening cosmetic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～9 and comparative example 1～17

[0063] The ingredients shown in Table 1 and Table 2 were processed according to the following preparation methods to prepare whitening cosmetics and evaluated. The preparation method and evaluation method are as follows.

[0064]

[0065] Cosmetics of Examples 1 to 9 and Comparative Examples 1 to 17 were prepared according to the composition of ingredients shown in Table 1 and Table 2 according to the following preparation method, and evaluated.

[0066] (Preparation of Examples 1, 2, 6 and Comparative Examples 1 to 17)

[0067] Dissolve bone collagen and sodium chondroitin sulfate in purified water, mix lecithin or hydrogenated lecithin with unsaturated fatty acids, vitamin E, add 1,3-butanediol, carboxyvinyl polymer, potassium hydroxide, para Methylparaben, stirred to mix, to prepare serum.

[0068] (preparation of embodiment 3,5,9) [make liposome complex by preparation method B]

[0069] Mix lecithin or hydrogenated lecithin, unsaturated fatty acid and vitamin E evenly...

Embodiment 4

[0081] Regarding Example 4 and Comparative Examples 4 and 11, the skin permeability of linoleic acid was evaluated. The back skin of the hairless mice was excised, and installed in a diffusion cell using saline as a storage solution. While incubating at 37°C, apply 0.5ml of the test product on the skin, extract the linoleic acid in the skin over time, and recover the residual linoleic acid from the coated test product. Quantification by phase chromatography. Taking the linoleic acid contained in the test product after application as 100, the skin penetration rate of linoleic acid at each time point was calculated.

[0082] The results are shown in Tables 1-2 and Figure 1~2 .

[0083] Table 1 Note) The compounding amount is expressed in w / w%.

[0084] Table 2 Note) The compounding amount is expressed in w / w%.

[0085] From Table 1~2 and figure 1 It can be seen that the examples containing unsaturated fatty acid or its derivatives, phospholipids, an...

Embodiment 10

[0088] [Example 10] (lotion)

[0089] Ingredients Dosage (%)

[0090] γ-linolenic acid 0.1

[0091] Glycerin 5.0

[0092] Soy Lecithin 0.35

[0093] Vitamin E 0.01

[0094] Hydrolyzed elastin solution 1.0

[0095] Sodium Hyaluronate 0.05

[0096] Methylparaben 0.05

[0097] Ethanol 8.0

[0098] Citric acid 0.05

[0099] Sodium citrate 0.07

[0100] Spice 0.05

[0101] Purified water balance

[0102] Total 100.0

[0103] (preparation method)

[0104] Dissolve hydrolyzed elastin solution and sodium hyaluronate in purified water. In addition, mix γ-linolenic acid with soybean lecithin and vitamin E, add it to the above aqueous solution, add glycerin, citric acid, sodium citrate, ethanol, methyl p-hydroxybenzoate, spices, and stir evenly to obtain lotion .

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Abstract

A skin-lightening cosmetic which contains an unsaturated fatty acid or a derivative thereof as the active ingredient, is highly effective in making the color of pigmentary deposits on the skin lighter at a lower concentration, and is highly safe. The cosmetic comprises (A) at least one member selected among C18-22 unsaturated fatty acids having 2 to 6 double bonds in the molecular structure and derivatives of the acids, (B) a phospholipid, (C) an antioxidant, (D) at least one member selected among proteins and hydrolyzates thereof, and (E) at least one member selected among mucopolysaccharides and salts thereof.

Description

field of invention [0001] The present invention relates to a whitening cosmetic for disappearing, lightening or preventing skin darkening caused by ultraviolet rays or skin pigmentation such as age spots and freckles. Background of the invention [0002] One of the aging phenomena of the skin is the appearance of abnormal pigmentation such as so-called age spots such as liver spots and age spots. These hyperpigmentation disorders are known to be exacerbated by ultraviolet rays, and for their prevention, ultraviolet protective agents and the like can be used. Whitening cosmetics using vitamin C, placenta extract, kojic acid, arbutin, unsaturated fatty acids, and the like as active ingredients are known as substances capable of reducing already-onset dyspigmentation. Among them, unsaturated fatty acids represented by linoleic acid (Linoleic acid) are known to have an excellent effect on reducing pigmentation generated in the skin (refer to Journal of Japanese Cosmetic Technol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/30A61K8/00A61K8/02A61K8/14A61K8/36A61K8/37A61K8/55A61K8/58A61K8/64A61K8/65A61K8/67A61K8/72A61K8/73A61K8/96A61Q19/00A61Q19/02A61Q19/10
CPCA61K8/678A61K8/553A61K8/37A61K8/361A61K8/67A61K8/735A61K8/65A61K8/676A61K8/14A61K8/64A61K8/0212A61Q19/10A61Q19/02A61K8/375A61K8/36A61K8/68
Inventor 今中宏真安藤秀哉牧野武利
Owner SUNSTAR KK
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