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Orally disintegrating tablet of 'Shengmai' and its preparation

A technology of orally disintegrating tablets and Shengmai, which is applied in the field of Shengmai orally disintegrating tablets and its preparation, can solve the problems of not finding Shengmai orally disintegrating tablets, and achieve good pharmacological effects and rapid onset of effects

Inactive Publication Date: 2006-10-04
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The Shengmai capsule with the standard number WS3-B-1312 records the extraction method. During the extraction process, ginseng polysaccharides, Ophiopogon polysaccharides, and Schisandra polysaccharides were not extracted, and part of the active ingredients were discarded. It is a pity (China Pharmaceutical University Acta Sinica, 2002, 33(1): 38-41); no patents related to Shengmai orally disintegrating tablets were found

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] (1) The raw material prescription of the present invention is:

[0072] Ginseng is 330g, Ophiopogon is 660g, Schisandra is 330g;

[0073] (2) Take ginseng and Ophiopogon japonicus decoction pieces, crush them, put them in a traditional Chinese medicine multifunctional extraction tank, extract them with 6 times, 50% ethanol for 1 hour, extract twice, filter, combine the extracts to recover the ethanol to the end, after extraction The residue is dried for later use; the extract is applied to the D101 type macroporous adsorption resin column, first eluted with distilled water, eluted with distilled water 10 times the column volume, the eluent is discarded, and then eluted with 50%. Ethanol is 6 times the column volume, and the eluent is recovered to the end of the ethanol to obtain 16.0 g of the effective parts of ginseng and Ophiopogon japonicus;

[0074] (3) Take schisandra, crush and put in CO 2 In the extraction kettle of the supercritical extraction equipment, adjust the ...

Embodiment 2

[0080] (1) The raw material prescription of the present invention is:

[0081] Ginseng is 330g, Ophiopogon japonicus is 660g, Schisandra is 330g;

[0082] (2) Take ginseng and Ophiopogon decoction pieces, crush them, put them in a traditional Chinese medicine multifunctional extraction tank, extract with 8 times 80% ethanol for 3 hours, extract 4 times, filter, combine the extracts to recover the ethanol to the end, after extraction The residue is dried for later use; the extract is applied to the AB-8 type macroporous adsorption resin column, first eluted with distilled water, the elution is 15 times the column volume with distilled water, the eluent is discarded, and then eluted with 80%. The amount of ethanol removed is 10 times the column volume, and the eluate is recovered to the end of the ethanol to obtain 33.0 grams of effective parts of ginseng and Ophiopogon japonicus;

[0083] (3) Take schisandra, crush and put in CO 2 In the extraction kettle of the supercritical extra...

Embodiment 3

[0088] (1) The raw material prescription of the present invention is:

[0089] Ginseng is 330g, Ophiopogon japonicus is 660g, Schisandra is 330g;

[0090] (2) Take ginseng and Ophiopogon decoction pieces, crush them, put them in a traditional Chinese medicine multifunctional extraction tank, extract with 7-fold, 55% ethanol for 2 hours, extract 3 times, filter, combine the extracts to recover the ethanol to the end, after extraction The residue is dried for later use; the extract is applied to the NKA-type macroporous adsorption resin column, first eluted with distilled water, eluted with distilled water 11 times the column volume, the eluent is discarded, and then eluted with 55, eluted with ethanol It is 7 times the column volume, and the eluate recovers ethanol to the end, and 29.4 grams of effective parts of ginseng and Ophiopogon japonicus are obtained;

[0091] (3) Take schisandra, crush and put in CO 2 In the extraction kettle of the supercritical extraction equipment, adju...

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Abstract

The invention discloses an orally disintegrating tablet of 'Shengmai' and its preparation characterized in that the tablet comprises the significant portions extracted from traditional Chinese medicinal panax ginseng, ophiopogon root, schisandra fruit and other medical use findings, the invention is also characterized that composite disintegrating tablet containing tetrahydroxy butane is employed, wherein the composite disintegrating tablet is obtained by combining tetrahydroxy butane with low substituted Hydroxypropylmethyl cellulose or sodium carboxymethylstarch or crossbond sodium carboxymethylstarch or insoluble cross bond polyvinylpyrrolidone by a finite proportion, the tetrahydroxy butane has the action of taste rectifying agent, thus reducing the consumption of medicinal findings in the preparation. Pharmacological experiment has shown that the disintegrating tablet has the advantages of quick disintegration, fast effect, and better pharmacological actions.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and specifically relates to a Shengmai orally disintegrating tablet and a preparation method thereof. Background technique [0002] Orally disintegrating tablet is a new pharmaceutical preparation, which can be absorbed through the sublingual mucosa and directly into the blood, effectively avoiding the first-pass effect, so the dosage is small, the safety is good, and the effect is rapid. Although it is an oral preparation, it can achieve the effect of an injection preparation. Therefore, it is gradually becoming a hot spot for pharmaceutical companies and R&D fields. This dosage form is mainly to choose a suitable fast disintegrant, and the tablets made from it have a certain hardness and a certain degree of porosity. There is no need to use water to assist in swallowing, and it can quickly disintegrate into fine particles in the oral cavity, and the medication can be co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61K36/57A61K36/258A61K9/20A61P9/00A61P9/10
Inventor 张晴龙
Owner 张晴龙
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