Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicinal preparation containing brucea fruit oil

A soft capsule preparation, the technology of bruce chinensis oil is applied in the directions of capsule delivery, medical preparations containing active ingredients, plant raw materials, etc., and can solve the problems of lack of beneficial effects of soft capsules, providing scientific prediction, complex physical and chemical properties, and the like. Significant stability and therapeutic benefits, enhanced beneficial effects, quantitatively accurate effects

Active Publication Date: 2006-12-06
江苏万高药业股份有限公司
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no one has provided a scientific prediction on the beneficial effects of soft capsules containing Brucea javanica oil, given the complexity of its physicochemical properties and the problems that have arisen in its clinical application

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Soft Capsules Containing Contents in Emulsion Form

[0033] Put an appropriate amount of gelatin into the sol tank, add an appropriate amount of water at 80-60°C, add preservatives, opacifiers and colorants if necessary, seal it and heat it at the same time, stir until it melts and swells completely, add an appropriate amount of glycerin, and seal the glue tank , turn off the stirring, turn on the vacuum pump, evacuate, and wait until the air bubbles are exhausted to obtain the gelatin solution. Keep warm at 70-50°C for later use.

[0034] Take the crude javanica javanica oil extracted with petroleum ether, heat it in a water bath to 80°C, add an appropriate amount of kaolin, heat for 40 minutes, filter while it is hot, and heat-treat at 160°C for 2 hours to obtain refined javanica javanica oil.

[0035] Take 15g of refined soybean lecithin, 10ml of glycerin, 15g of sorbitol, 10g of vitamin E and 50ml of polyethylene glycol-400, mix them with ...

Embodiment 2

[0036] Embodiment 2: the soft capsule that contains inclusion compound form content

[0037] The soft capsule material and the refined oil of Brucea javanica are the same as in Example 1.

[0038] Take 1g of refined Brucea javanica oil, add 5ml of petroleum ether, stir until completely dissolved; take another 20g of 2-hydroxypropyl-β-cyclodextrin, add 20ml of water to dissolve, add Brucea javanica oil solution to 2-hydroxypropyl In the solution of base-β-cyclodextrin, a uniform cyclodextrin inclusion complex is made. After the clathrate is dried and the petroleum ether is evaporated, an appropriate amount of Tween, glycerin, sorbitol and beeswax is added, mixed evenly, and pressed to obtain the finished product.

[0039] Confirmed by the X-ray diffraction method, it is confirmed that the prepared pharmaceutical composition is in the form of clathrate.

Embodiment 3

[0040] Embodiment 3: the soft capsule that contains lipoplex form content

[0041] The soft capsule material and the refined oil of Brucea javanica are the same as in Example 1.

[0042] Prepare liposomes by taking soybean lecithin, phosphatidylinositol, cholesterol and vitamin E, adding buffer to prepare liposome solution, adding Brucea javanica oil, and homogenizing with a high-speed shear homogenizer. An appropriate amount of thickener is added to make the solution more stable.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides a soft medicine capsule with brucea fruit oil loaded in the emulsion type, self-emulsifying type, clathrate type, composite phospholipid type or common solvent type inclusion. The soft medicine capsule has reinforced beneficial effect of brucea fruit oil as well as obvious stability and high curative effect.

Description

technical field [0001] The invention relates to a pharmaceutical soft capsule preparation, in particular to a pharmaceutical preparation containing javanica javanica oil, which can significantly enhance the beneficial effect of javanica javanica oil. Background technique [0002] Brucea javanica, also known as "old gallbladder". Since the early 1980s, after researchers at Shenyang Pharmaceutical University discovered that Brucea javanica has significant physiological activities, it has been widely used to treat cancer and tumors, especially for various stages of cancer such as esophageal cancer, gastric cancer, intestinal cancer and The curative effect of liver cancer is excellent. The components of Brucea javanica can be divided into two parts: water-soluble and fat-soluble, among which the research on the fat-soluble part is more sufficient. Brucea javanica oil is a brownish-yellow, clear oily liquid, the main active ingredients of which are oleic acid and linoleic acid,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/48A61K36/185A61P35/00
Inventor 徐新盛文艳秋
Owner 江苏万高药业股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com