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Prepn process of degradable bioactive film

A bioactive and degradable film technology, applied in the field of bioactive degradable film preparation, can solve the problems of high price, long degradation time, and infrequent use, and achieve the effects of increasing toughness, improving degradation rate and good wet strength

Inactive Publication Date: 2007-07-25
杨晓霞 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, polylactic acid and chitosan are commonly used as raw materials for preparing biodegradable polymers. The conditions for polylactic acid synthesis are relatively high, and most of them are imported, and the price is expensive; the degradation film made of polylactic acid takes a long time to degrade in the body. Therefore, it is not often used in China

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] 1. Gelatin is completely dissolved in balanced salt solution PBS solution to make a 3% solution.

[0019] 2. Chitosan is completely dissolved in citric acid-phosphate buffer solution and made into a 3% solution.

[0020] 3. Dissolve polyvinyl alcohol in double-distilled water to make a 10% solution, and make it completely dissolved into a colorless and transparent gel.

[0021] 4. Take gelatin solution, chitosan solution, and polyvinyl alcohol solution. After these three solutions are completely mixed in a ratio of 6:5:5, spread them on a glass plate, and dry naturally at room temperature to form a film.

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PUM

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Abstract

The present invention provides one kind of degradable bioactive film and solves the technological problem of providing degradable bioactive film with relatively low cost and relatively fast intracorporeal degrading speed. The degradable bioactive film is prepared through dissolving gelatin in PBS solution to compound 0.3-5 % gelatin solution; dissolving chitosan in citric acid-phosphoric acid buffering liquid to compound 0.5-5 % chitosan solution; dissolving PVA in double distilled water to compound 3-15 % PVA solution; mixing gelatin solution, chitosan solution and PVA solution in the ratio of 4-8 to 2-7 to 3-7; spreading the mixed solution on glass plate and drying naturally in room temperature to form the film. The degradable bioactive film has ideal delayed releasing bioactivity and relatively fast degradation in body.

Description

technical field [0001] The invention relates to a preparation method of a bioactive degradable film Background technique [0002] Biodegradable polymer is a kind of artificially synthesized organic compound, which can be degraded and absorbed in the body, non-toxic, non-accumulating, and has good biocompatibility. It has been widely used in absorbable sutures, slow-release carriers of drugs, Bone plates and set screws, etc. In particular, the study as a drug sustained release carrier has attracted people's attention. The role of the biodegradable polymer carrier in the drug controlled release system is to enable the drug to release the drug at a zero-order kinetic rate or other controllable rate, and then the drug release is exhausted, and the polymer carrier itself is degraded into small molecular substances , and be absorbed or excreted by the body. The polymer carriers usually used for drug controlled release are mainly polyesters and amino acids, mainly some chemical ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L29/04C08B37/08C08J5/18
Inventor 杨晓霞辛畅泰孙佩杰李娜然孟祥君莫忆南刘伟梁晓旭魏侃
Owner 杨晓霞
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