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Process for extracting and refining tanshinone IIA by supercritical CO2

A carbon dioxide, supercritical technology, applied in the direction of organic chemistry, bulk chemical production, etc., to achieve the effect of simple process operation, not easy to degrade, and avoid the use of organic solvents

Inactive Publication Date: 2002-09-18
广州美晨药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Zhang Kun, Liu Jialiang, etc. published the research on the carbon dioxide supercritical fluid extraction process of tanshinone IIA "Journal of South China University of Technology, 26 (8), 91-93, 1998", which only involved supercritical carbon dioxide extraction of tanshinone IIA, but did not treat the active ingredients. Refined Tanshinone IIA

Method used

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  • Process for extracting and refining tanshinone IIA by supercritical CO2

Examples

Experimental program
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Effect test

Embodiment 1

[0015] Put 359g of commercially available traditional Chinese medicine salvia miltiorrhiza into the extraction kettle, keep the extraction pressure at 30MPa, and the extraction temperature at 40°C; the rectification column pressure at 7.5MPa, and the rectification temperature at 25°C, 3.59g of refined tanshinone IIA extract can be obtained; The pressure of the device is 6.5MPa, the separation temperature is 15°C, and 7.18g of fat-soluble extract and impurities can be obtained. The content of the active ingredient tanshinone IIA in the extract refined by the rectification column is 87%, and the yield of tanshinone IIA is 91%.

Embodiment 2

[0017] Put 582g of commercially available traditional Chinese medicine salvia miltiorrhiza in the extraction kettle, keep the extraction pressure at 40MPa, and the extraction temperature at 65°C; The pressure is 10MPa, the separation temperature is 55°C, and 13.4g of fat-soluble extract and impurities can be obtained. The content of active ingredient tanshinone IIA in the extract refined by rectification column is 89%, and the yield of tanshinone IIA is 98%.

Embodiment 3

[0019] Put 590g of commercially available traditional Chinese medicine salvia miltiorrhiza into the extraction kettle, keep the extraction pressure at 45MPa, and the extraction temperature at 75°C; the rectification column pressure at 32MPa, and the rectification temperature at 75°C, 1.8g of refined tanshinone IIA extract can be obtained; The pressure is 25MPa, the separation temperature is 75°C, and 11.6g of fat-soluble extract and impurities can be obtained. The content of active ingredient tanshinone IIA in the extract refined by rectification column is 95%, and the yield of tanshinone IIA is 37%.

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Abstract

A process for extracting and refining tanshinone IIA by supercritical CO2 includes loading pwodered red sage root in extractor, extracting at 32-80 deg.C and 30-45 MPa, rectifying the supercritical CO2 fluid in which the extract is dissolved at 25-75 deg.C and 7.5-32 MPa, and separating at 15-75 deg.C and 6.5-25 MPa. Its advantages are high purity up to 80-95% and output rate up to 90% or more, not degradating easily and cyclic use of CO2.

Description

technical field [0001] The invention relates to a method for extracting and refining tanshinone IIA, an effective component of salvia miltiorrhiza. Background technique [0002] As a traditional Chinese medicine, Salvia miltiorrhiza has the effects of promoting blood circulation, regulating menstruation, removing blood stasis, relieving pain, nourishing the heart and calming the nerves, and its preparations are widely used clinically. Tanshinone is the total ketone extracted from Salvia miltiorrhiza, and it is the main active ingredient. Among them, tanshinone IIA is one of the active ingredients that must be detected in the Chinese Pharmacopoeia. Tanshinone IIA is widely used in industrial fields such as medicine and cosmetics. [0003] The existing methods for extracting the active ingredient of Danshen tanshinone IIA are mostly organic solvent extraction and supercritical carbon dioxide extraction. The organic solvent extraction method is to use ethanol as a solvent, he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/79C07D307/94
CPCY02P20/54
Inventor 姚煜东金波胡耀昌莫启武刘汉槎
Owner 广州美晨药业有限公司
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