Veterinary compositions for the treatment of parasitic diseases

A technology of composition and animal parasites, which is applied in the direction of drug combination, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem that there is no report on the improvement of the absorption rate of Rafoxanide

Inactive Publication Date: 2003-03-26
NEW PHARMA RES SWEDEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no increased absorption of rafoxanide has been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] The composition contains:

[0060] Rafnet 2.5%

[0061] NMP 4%

[0062] Tween® 80 10%

[0063] 2-pyrrolidone q.s.p.100ml

Embodiment 2

[0065] The composition contains:

[0066] Rafnet 2.5%

[0067] Tween® 80 8%

[0068] NMP q.s.p.100ml

Embodiment 3

[0070] The composition contains:

[0071] Rafnet 2.5%

[0072] 2-Pyrrolidone 30%

[0073] Tween® 80 10%

[0074] DMSO 20%

[0075] NMP q.s.p.100ml

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PUM

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Abstract

Micellar non-aqueous or aqueous compositions for the therapeutic treatment of animal diseases caused by parasitic worms or nematodes, comprising rafoxanide and specific combinations of solvents which act as stabilising and absorption-promoting agents. The solvents are selected from non-ionic surface-active agents such as Tween*80 and from N-methylpyrrolidone, 2-pyrrolidone or dimetylsulfoxide. The compositions are easy to prepare, stable upon storage and can be administered orally, by injection or topically. With these formulations, an improvement of the efficacy of rafoxanide in the treatment of the diseases is observed.

Description

field of invention [0001] The present invention relates to compositions comprising rafoxanide intended for use in the veterinary field, preferably for the treatment of parasitic diseases of farm and domestic animals, such as liver fluke or bosomia infestation. Background of the invention [0002] Rafoxanide is the generic name for 3'-chloro-4'-(4-chlorophenoxy)-3,5-diiodosalicylanilide. Rafoxet is sold for example by Pfizer Animal Health Inc. of Zimbabwe under the trade name Ranox(R) or by Ventron of India. [0003] Rafoxanide is known to be useful as an anthelmintic and fascicide, effective in the treatment of parasitic diseases affecting animals and caused by parasitic helminth or nematode infections. [0004] Rafoxanide is also known to be extremely water insoluble (see eg Nessel German Patent 1472 385), its solubility in water at 25°C being approximately 0.005% w / v. [0005] Efforts to increase the solubility of rafoxanide have included surfactants in the composition. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/60A61K47/22A61P33/00
CPCA61K9/0019A61K31/60A61K9/1075A61K47/22A61K31/609A61P33/00
Inventor A·R·舒艾阿
Owner NEW PHARMA RES SWEDEN
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