Process for preparing 3-hydroxy-3-methylbutyrate (HMB) amino acid salt

A technology of amino acid salt and methylbutyric acid, which is applied in the preparation of cyanide reaction, chemical instruments and methods, and the preparation of organic compounds, etc., can solve the problems of inability to reduce body fat, achieve high oral bioavailability, and reduce body fat , the effect of little environmental pollution

Inactive Publication Date: 2003-08-06
EAST CHINA NORMAL UNIVERSITY
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Problems solved by technology

But the results show that mixed oral administration can only pro

Method used

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Embodiment 1～7

[0015] Prepare HMB amino acid salt according to the above preparation method, the operations of the first and second steps are all the same:

[0016] The consumption of NaOH and water is respectively 100g and 400g in the first step;

[0017] In the second step, diacetone alcohol, water, NaHSO 3 The consumption of HCl and HCl is respectively 46g, 120g, 8g and 120g, and each consumption of isobutanol is 150g;

[0018] The third step operation of each embodiment is as follows:

Embodiment 1

[0020] The consumption of water and L-arginine in the third step is 120g and 28g respectively, obtains product HMB-L-arginine salt 47g.

Embodiment 2

[0022] The consumption of water and D-arginine in the third step is 120g and 28g respectively, obtains product HMB-D-arginine salt 47g.

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Abstract

The method for preparing 3-hydroxy-3-methylbutyric acid (HMB) amino acid salt uses diacetone alcohol as raw material and includes the following steps: making haloform reaction in water, adopting isobutanol to extract the produced HMB acid, then making the isobutanol layer and amino acid form salt in alcohol-water mixed liquor so as to obtain the invented product. Its product purity is high, and environment pollution is less, after said product is taken in, it can be completely fed into blood plasma and can be absorbed by human body. Said product can be used for promoting growth of musculus ofhuman body, reducing fat and raising immunological function of human body.

Description

technical field [0001] The invention relates to a preparation method of 3-hydroxy-3-methylbutyric acid (HMB) amino acid salt, belonging to the technical field of organic compound preparation. The amino acid part of HMB amino acid salt can be L-arginine, D-arginine, DL-arginine, dipeptide L-aminoacetyl arginine, dipeptide D-aminoacetyl arginine, dipeptide DL-aminoacetyl arginine, dipeptide L-α-aminopropionyl arginine, dipeptide D-α-aminopropionyl arginine, dipeptide DL-α-aminopropionyl arginine, dipeptide L-aminoacetyl glutamine, dipeptide D-aminoacetyl glutamine, DL-aminoacetyl glutamine, dipeptide L-alpha-aminopropionyl glutamine, dipeptide D-alpha-aminopropyl Acyl glutamine, dipeptide DL-α-aminopropionyl glutamine. Background technique [0002] HMB is a metabolite of leucine in the human body. U.S. patent reports that it can enhance the immunity of mammals (US 4992470), promote human muscle growth (US 5028440), reduce body fat, that is, total cholesterol a...

Claims

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Application Information

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IPC IPC(8): C07C227/16C07C229/22C07C229/26C07K5/06
Inventor 汤杰杨帆邹刚洪镛裕
Owner EAST CHINA NORMAL UNIVERSITY
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