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Medication for treating cancer and chronic hepatitis B and its prepn. method

A chronic hepatitis B, drug technology, applied in the field of preparation of the drug, can solve the problems of side effects, high price, inconsistent clinical curative effect, lack of anti-HBV, etc., to enhance the immune function of the body, high bioavailability, clear or The effect of inhibiting replication

Inactive Publication Date: 2004-03-10
广东天之骄药物开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, there have been medicines for the treatment of chronic hepatitis B at home and abroad, with different clinical curative effects. INF-α is recognized both at home and abroad, but the negative conversion rate of HbeAg and HBV DNA is only about 40%, and the curative effect is far from ideal. Due to certain side effects and high price, the clinical practice is limited
At present, there is a lack of anti-HBV drugs with definite curative effect and no side effects in the market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Below by embodiment and main pharmacodynamics test the present invention will be further described. The preparation of embodiment 1 freeze-dried powder injection

[0026] (1) Take 100g of ginseng, heat and reflux with 75% ethanol to extract 4 times, each time for 1 hour, and ginseng medicinal residues for later use; combine the extracts, recover the ethanol under reduced pressure, add 1.5 times the amount of water, stir well, and refrigerate for 42 hours , filtered, the filtrate was applied to a macroporous adsorption resin chromatography column, eluted with water and 60% ethanol successively, collected 600% ethanol eluate, recovered under reduced pressure and concentrated to a relative density of 1.18 (60 ° C), dried, Get ginseng extract.

[0027] (2) Take 315g of Astragalus membranaceus and ginseng dregs, add water to decoct 3 times, 1.5 hours each time, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.12 (...

Embodiment 2

[0030] The preparation of embodiment 2 injection

[0031] (1) Take 110g of ginseng, heat and reflux with 70% ethanol to extract 3 times, each time for 2 hours, and ginseng medicinal residues for later use; combine the extracts, recover the ethanol under reduced pressure, add 2 times the amount of water, stir well, and refrigerate for 48 hours , filtered, the filtrate was applied to a macroporous adsorption resin chromatography column, eluted with water and 60% ethanol successively, collected 60% ethanol eluate, recovered under reduced pressure and concentrated to a relative density of 1.20 (60° C.), dried, Get ginseng extract.

[0032] (2) Take 300g of Astragalus membranaceus and ginseng dregs, add water to decoct 3 times, 2 hours each time, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.15 (60°C), add ethanol to make the alcohol content reach 75%, refrigerated for 48 hours, and precipitated for later use; the sup...

Embodiment 3

[0035] The preparation of embodiment 3 big infusion

[0036] (1) Get 320 g of Radix Astragali, 105 g of Radix Ginseng, and 10 g of Kushensu, and prepare Radix Ginseng Extract, Extract of Radix Radix Astragali, and total polysaccharides respectively with (1) (2) (3) in Example 2.

[0037] (2) Take 11g of the above-mentioned ginseng extract, astragalus extract, total polysaccharides and matrine, add 2000ml of water for injection and 15g of sodium chloride, stir and dissolve, adjust the pH to 6-7 with 40% sodium hydroxide solution, and let stand for 40 hour, filtered, and the filtrate was filtered with a filter membrane of 0.45um and 0.22um respectively, and the filtrate was potted in a 100ml infusion bottle, sterilized, quality checked, and the large infusion solution of the present invention was obtained. main efficacy test

[0038] The first part of the present invention freeze-dried powder injection anti-tumor pharmacological effect experimental research 1, test materials 1 dr...

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PUM

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Abstract

A Chinese medicine for treating cancer and hepatitis B is prepared from astragalus root, ginseng and kurarnol. Its advantages are sure curative effect, quickly taking its effect and no toxic by-effect.

Description

Technical field [0001] The invention relates to a medicine for treating cancer and chronic hepatitis B, in particular to a Chinese patent medicine prepared from traditional Chinese medicines, and also relates to a preparation method of the medicine. Background technique [0002] Despite great advances in medical research, cancer remains the leading cause of death for humans. According to the different parts of the disease, there are: liver cancer, lung cancer, rectal cancer, malignant lymphoma, gynecological malignant tumor, etc. Conventional methods of cancer treatment, such as surgery, chemotherapy, radiotherapy and interventional therapy, only treat the symptoms but not the root cause, which brings great harm to the patient. Painful, while killing cancer cells, it also kills normal cells, causing people's immune function to decline, the treatment effect is not very good, the cure rate is low, and many tumors are resistant to these conventional treatment methods and have r...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/19A61P1/16A61P31/12A61P35/00
Inventor 王习著
Owner 广东天之骄药物开发有限公司
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