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Slow releasing micro-encapsulation compound antioxidant

A microencapsulation and anti-oxidant technology, which is applied in the direction of anti-toxic agents, chemical instruments and methods, and compositions for inhibiting chemical changes, etc., can solve the problem of strong antioxidant activity of catechins, poor stability, easy oxidation inactivation, stability and Poor fat solubility and other problems, to achieve the effect of increased antioxidant activity in vitro, good stability, and enhanced fat solubility

Inactive Publication Date: 2004-03-17
长沙国藩科技有限公司
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The disadvantage of the strong antioxidant activity of catechin is that it is less stable and prone to oxidative inacti

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: (1) the preparation of sustained-release type microencapsulated compound antioxidant capsule core substance: 575 grams of catechins, 200 grams of vitamin C, 120 grams of beta-carotene, 100 grams of coenzyme Q, 2 grams of sodium sulfite, B 3 grams of diaminohexanoic acid. (2) Preparation of microcapsules: the capsule core material is dissolved in 3000 milliliters of absolute ethanol, then 1000 milliliters of 5% chitosan acetic acid solution is prepared, fully stirred at 800 rpm for 2 hours, and the capsule core material is slowly added Chitosan acetic acid solution, 800 rpm fully stirred for 1-2 hours. The dispersion liquid is spray-dried to obtain compound antioxidant microcapsules with chitosan as the matrix. Then fully disperse the ethyl cellulose in dichloromethane, add chitosan microcapsules, fully stir at 800 rpm, stir to make it evenly dispersed in the ethyl cellulose emulsion, add 2 times the volume of sherwood oil, Stir well at 800 rpm to make th...

Embodiment 2

[0013] Embodiment 2: (1) Preparation of slow-release microencapsulated compound antioxidant capsule core substance: 620 grams of catechins, 180 grams of vitamin C, 90 grams of beta-carotene, 100 grams of coenzyme Q, sodium bisulfite 5 gram, EDTA 5 grams. (2) Preparation of microcapsules: Carry out according to the method in Example 1.

[0014] The test results show that the fat solubility of catechin is 10 times higher than that of catechin, the stability is 4 times higher than that of catechin, the antioxidant activity in vitro is 2 times higher than that of catechin, and the antioxidant activity in vivo is higher than that of catechin. prime increased 7-fold.

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PUM

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Abstract

The microcapsulized compound antioxidant consists of catechin 50-70 wt%, vitamin C 10-30 wt%, beta-carotene 5-15 wt%, coenzyme Q 5-10 wt%, sodium sulfite or sodium bisulfite 0.1-1.0 wt% and ethylene diamine hexylacetic acid 0.1-1.0 wt%; and is microcapsulized with biological slow releasing filming material vinyl cellulose and chitosan as wall material. It has better elimination effect on various free radicals, liposolubility higher than catechin and high bioutilization of catechin. The antioxidant may be used for health food, food preservation, oil antioxidation, toothpaste, cosmetics, etc. for resisting senility and preventing and treating free radical relevant diseases.

Description

technical field [0001] The invention relates to a broad-spectrum high-efficiency antioxidant. Especially microencapsulated compound antioxidants that can be released in sustained release form. Background technique [0002] Free radicals in the body are mainly divided into three categories: semiquinone free radicals, oxygen free radicals, various amino acids, nucleotide bases, and carbon-sulfur center free radicals produced by other biological molecules. Excess free radicals are an important damage factor that causes cell destruction and body damage. The toxic reaction of free radicals is closely related to the occurrence of inflammation, immune diseases, radiation damage, aging and tumors. The substances that compete with free radicals are antioxidants. [0003] Currently commonly used antioxidants mainly include vitamin C and vitamin E. Vitamin C is mainly used to scavenge OH, but it needs to be used in large doses to achieve the purpose, but at the same time, the use of...

Claims

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Application Information

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IPC IPC(8): A23L3/3463A61K9/52A61K33/04A61P39/06C09K15/28
Inventor 何小解
Owner 长沙国藩科技有限公司
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