Heat-resistant lyophilized protectant of lyophilized vaccine for henpox and preparing process thereof

A heat-resistant freeze-drying and protective agent technology, applied in freeze-dried transportation, antiviral agents, non-active ingredients of polymer compounds, etc., can solve problems such as no detailed reports on methods

Inactive Publication Date: 2004-09-15
卫广森
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[0007] The heat-resistant freeze-drying protectant for fowlpox freeze-dried vaccine includes commonly used gelatin and lactose. PVP (K90) 5%, sorbitol 2%, sodium glutamate 1%, beef peptone 2%, bovine serum albumin 1%, Vc 0.1%; the preparation is a dry matter component, and the rest of the percentage is distilled water.

[0008] The preparation process of the heat-resistant freeze-drying protective agent for fowlpox freeze-dried vaccine comprises mixing the dry matter components of the above-mentioned heat-resistant freeze-drying protective agent in proportion, and is characterized in that the effective material components of the protective agent are sterilized respectively: (1) For gelatin, lactose, beef peptone, EDTA, and PVP (90) that can be autoclaved, dissolve them in distilled water according to their respective proportions, and sterilize them at 116°C for 30-40 minutes; Parts of bovine serum albumin, sorbitol, sodium glutamate, and Vc are all dissolved in distilled water...

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Abstract

The present invention relates to a heat-resisting freeze-dried protection agent for chicken pox freeze-dried vaccine and its preparation process. It is characterized by that its composition includes gelatin 3%, lactose 5-6%, EDTA 2%, PVP (K90) 5%, sorbitol 2%, sodium glutamate 1%, beef peptone 2%, bovine serum albumin 1% and Vc 0.1%, and the rest is distilled water. Said invention also provides its preparation method and concrete steps, and its application.

Description

technical field [0001] The invention relates to a freeze-drying technology of biological products, a preservation auxiliary agent and a manufacturing method thereof. Background technique [0002] The commonly used protective agents for veterinary biological products in my country are mainly 5% sucrose skimmed milk, 5-10% sucrose, and 1.5-3% gelatin. -9 months, must be used up as soon as possible at room temperature. This brings many difficulties and inconveniences to the preservation, transportation, use, etc. of veterinary biological products. At the same time, energy consumption and storage costs are high due to the necessity of low-temperature preservation. [0003] At present, almost all veterinary biological freeze-dried products in developed countries in the world are stored at 2-8°C for more than 24 months. But there is no detailed report on the method. Chinese patent CN1176827A "A Manufacturing Method for Freeze-dried Live Vaccines for Animals" proposes to use poly...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K31/275A61K47/42A61P31/20
Inventor 卫广森王文成张万林
Owner 卫广森
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