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Inclusion active substance improved vitamin U belladonna and aluminium capsule II

A technology of active ingredients and capsules, which is applied in the direction of capsule delivery, medical preparations containing active ingredients, drug combinations, etc., to achieve the effects of improving stability, extending shelf life, and eliminating odors

Active Publication Date: 2004-09-15
XIUZHENG PHARMA GROUP HOIDING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cyclodextrin is preferred in the present invention

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The formulation of the modified vitamin U belladonna aluminum capsule II containing active ingredients:

[0023] Vitamin U 50g

[0024] Aluminum hydroxide 140g

[0025] Belladonna Extract 10g

[0026] β-CYD 60g

[0027] Makes 1000 capsules.

[0028] Weigh 50 grams of β-CYD, add 100 ml of purified water, grind until uniform, and set aside;

[0029] Weigh 50 grams of Vitamin U, the active component of Vitamin U Belladonna Aluminum Capsule II II, add it to the β-CYD aqueous solution, grind for 20 minutes, until it becomes a paste;

[0030] Spread tray, thickness 1.5-2.5cm, dry at 40°C low temperature;

[0031] Pulverize, pass 80 mesh sieves;

[0032] Obtain vitamin U dry clathrate;

[0033] Weigh 10 grams of β-CYD, add 20 ml of purified water, grind until uniform, and set aside;

[0034] Weigh 10 grams of belladonna extract, the active component of vitamin U belladonna aluminum capsule II, add it to the -CYD aqueous solution, and grind for 20 minutes until it becom...

Embodiment 2

[0039] The formulation of the modified vitamin U belladonna aluminum capsule II containing active ingredients:

[0040] Vitamin U 50g

[0041] Aluminum hydroxide 140g

[0042] Belladonna Extract 10g

[0043] β-CYD 90g

[0044] Makes 1000 capsules.

[0045] Weigh 75 grams of β-CYD, add 150 ml of purified water, grind until uniform, and set aside;

[0046] Weigh 50 grams of vitamin U, the active component of vitamin U belladonna aluminum capsule II, add it to the β-CYD aqueous solution, grind for 25 minutes, until it becomes a paste;

[0047] Spread tray, thickness 1.5-2.5cm, dry at 40°C low temperature;

[0048] Pulverize, pass 80 mesh sieves;

[0049] Obtain vitamin U dry clathrate;

[0050] Weigh 15 grams of β-CYD, add 30 ml of purified water, grind until uniform, and set aside;

[0051] Weigh 10 grams of belladonna extract, the active component of vitamin U belladonna aluminum capsule II, add it to the β-CYD aqueous solution, and grind for 25 minutes until it becomes...

Embodiment 3

[0056] The formulation of the modified vitamin U belladonna aluminum capsule II containing active ingredients:

[0057] Vitamin U 50g

[0058] Aluminum hydroxide 140g

[0059] Belladonna Extract 10g

[0060] β-CYD 120g

[0061] Makes 1000 capsules.

[0062] Weigh 100 grams of β-CYD, add 150 milliliters of purified water, grind until uniform, and set aside;

[0063] Weigh 50 grams of vitamin U, the active component of vitamin U belladonna aluminum capsule II, add it to the β-CYD aqueous solution, grind for 25 minutes, until it becomes a paste;

[0064] Spread tray, thickness 1.5-2.5cm, dry at 40°C low temperature;

[0065] Pulverize and pass through an 80-mesh sieve to obtain dry inclusion complex of vitamin U;

[0066] Weigh 20 grams of β-CYD, add 30 ml of purified water, grind until uniform, and set aside;

[0067] Weigh 10 grams of belladonna extract, the active component of vitamin U belladonna aluminum capsule II, add it to the β-CYD aqueous solution, and grind for 25...

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Abstract

The present invention relates to a method for making inclusion of active components of improved vitamin U belladonna aluminium capsule II (Sidashu). It is characterized by that said invention respectively selects proper inclusion material, and its optimal inclusion material is cyclodextrin, and its optimal inclusion method is grinding method, the ratio of core material (active component) and inclusion material can select 1:1-1:5, and its optimal ratio is 1:1-1:2.5, and the optimal grinding time is 20-30 min. and the ratio of inclusion material and added water is 1:2-1:5. Said invented inclusion method can reduce the influence of light, heat, oxygen and hydrolysis on active components, and can raise its stability, prolong storage time, eliminate abnormal smell and can raise dissolubility and resolution of active components.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to inclusion of active components of the improved vitamin U belladonna aluminum capsule II, and the international patent classification number is A61K 9 / 00. Background technique [0002] Currently, the best-selling vitamin U belladonna aluminum capsule II (Starda Shu) is mainly composed of vitamin U, aluminum hydroxide, belladonna extract and the like. [0003] The existing formula of vitamin U belladonna aluminum capsule II: [0004] Vitamin U 50g [0005] Aluminum hydroxide 140g [0006] Belladonna Extract 10g [0007] Excipients Appropriate amount [0008] Makes 1000 capsules. [0009] Vitamin U is a sulfur-containing α-amino acid. It has a special smell and tastes bitter and salty. Its performance is unstable when it is exposed to light or exposed to the air for a long time. Light, heat and moisture can promote its decomposition and produce a special smell. Thi...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61P1/04
Inventor 张德桐王文仁柏青安
Owner XIUZHENG PHARMA GROUP HOIDING