Oral medicine for eliminating pyloric spirillar bacilli

A technology of Helicobacter pylori and drugs, which is applied in the directions of antibacterial drugs, drug combinations, and pharmaceutical formulations, can solve the problems of high frequency of use of antibacterial drugs, drug resistance, and impact on efficacy.

Inactive Publication Date: 2005-01-05
金春华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the antibacterial drugs invented by these patents are old drugs with high frequency of use, such as amoxicillin, clarithromycin, tinidazole, metronidazole, etc.
Drug resistance may occur (for example, the resistance rate of metronidazole in France is nearly 90%), affecting the efficacy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0096] Example 1: Laftidine ornidazole roxithromycin film-coated tablet

[0097] prescription:

[0098] Laftidine 5g

[0099] Ornidazole 250g

[0100] Roxithromycin 75g

[0101] Microcrystalline Cellulose 52.5g

[0102] Sodium carboxymethyl starch 45g

[0103] Povidone 18g

[0104] Magnesium Stearate 4.5g

[0105] Makes 1000 pieces

[0106] Grind lavutidine, ornidazole and roxithromycin separately, pass through a 80-mesh sieve, mix with microcrystalline cellulose, half a quantity of carboxymethyl starch sodium and povidone according to the prescription, moisten with appropriate amount of water, and make soft After drying, granulate, pass through a 20-mesh sieve, add the remaining half amount of sodium carboxymethyl starch and magnesium stearate, mix evenly, compress into tablets, coat with film, and pack after passing the inspection.

example 2

[0107] Example 2: Laftidine Ornidazole Roxithromycin Capsules

[0108] prescription:

[0109] Laftidine 5g

[0110] Ornidazole 250g

[0111] Roxithromycin 37.5g

[0112] Microcrystalline Cellulose 40g

[0113] Sodium carboxymethyl starch 45g

[0114] Povidone 18g

[0115] Magnesium Stearate 4.5g

[0116] Makes 1000 capsules

[0117] Pulverize lavutidine, ornidazole and roxithromycin respectively, pass through a 80-mesh sieve, mix with microcrystalline cellulose, croscarmellose sodium and povidone according to the prescription amount, moisten with appropriate amount of water, and prepare After drying, the soft material is granulated, passed through a 20-mesh sieve, added with magnesium stearate, mixed evenly, filled into capsules, and packed after passing the inspection.

example 3

[0118] Example 3: Laftidine Ornidazole Roxithromycin Sugar-Coated Tablets

[0119] prescription:

[0120] Laftidine 5g

[0121] Ornidazole 200g

[0122] Roxithromycin 75g

[0123] Microcrystalline Cellulose 102.5g

[0124] Sodium carboxymethyl starch 45g

[0125]Povidone 18g

[0126] Magnesium Stearate 4.5g

[0127] Makes 1000 pieces

[0128] Grind lavutidine, ornidazole and roxithromycin separately, pass through a 80-mesh sieve, mix with microcrystalline cellulose, half a quantity of carboxymethyl starch sodium and povidone according to the prescription, moisten with appropriate amount of water, and make soft After drying, granulate, pass through a 20-mesh sieve, add the remaining half amount of sodium carboxymethyl starch and magnesium stearate, mix evenly, compress into tablets, coat with sugar, and pack after passing the inspection.

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PUM

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Abstract

An orally-applied medicine for radically treating the pylorospirobacillus contains roxithromycin, histamine H2 recepto agonist, nitroimidazole-type antibacterial agent, and proper additive.

Description

technical field [0001] The invention relates to an oral pharmaceutical preparation for treating Helicobacter pylori infection. Background technique [0002] Helicobacter pylori (HP for short) is the main pathogenic factor of chronic gastritis, is highly related to peptic ulcer, and is a risk factor of gastric cancer. A large number of studies have shown that killing HP can treat chronic gastritis, accelerate ulcer healing, reduce ulcer recurrence, and reduce gastric cancer. Therefore, scholars at home and abroad have extensively discussed the methods of eradicating HP. Although HP is sensitive to many antibiotics in vitro, the eradication rate of HP with monotherapy is not high (only 15%-20%), and it is prone to recurrence and drug resistance. Therefore, both at home and abroad, two or more than two kinds of drugs are usually combined to treat HP. [0003] Since the Ninth World Gastrointestinal Congress recommended the first triple drug regimen to eradicate HP in 1990, ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P1/04A61P31/04
Inventor 金春华
Owner 金春华
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