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Preparation and application of a gene engineering vaccine of muscle growth retarder

A technology for muscle growth inhibition and genetic engineering vaccine, which can be used in DNA/RNA fragments, recombinant DNA technology, fermentation, etc., and can solve the problems of no production application prospect and complicated operation.

Inactive Publication Date: 2005-01-26
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

However, the "passive immunization" technology is only in the experimental stage at present. At the same time, the "passive immunization" method also requires daily injection of antibodies. Due to cumbersome operations and protests from foreign animal welfare activists, there is no prospect of production and application.

Method used

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  • Preparation and application of a gene engineering vaccine of muscle growth retarder
  • Preparation and application of a gene engineering vaccine of muscle growth retarder

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Embodiment Construction

[0019] specific implementation plan

[0020] The following is the description of using the myostatin coding cDNA cloned from lion head goose to prepare the genetic engineering vaccine of myostatin. Since the amino acid residue sequences of the mature peptides of myostatin in different animals found so far are very similar, in addition to using the myostatin gene of lion head goose, the muscle of chicken, pig, cattle and sheep can also be used The somatostatin gene is used to prepare a genetically engineered vaccine for myostatin.

[0021] The specific method is: (1) obtain or clone the myostatin coding gene of livestock and poultry, (2) use the gene to express the recombinant fusion protein of myostatin in Escherichia coli or yeast as an antigen or immunogen, (3) ) Purify the expressed myostatin fusion protein immunogen and mix it with mineral oil adjuvant to make myostatin vaccine.

[0022] 1. Cloning of animal myostatin-encoding cDNA

[0023] ① Ac...

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Abstract

The invention belongs to the preparation field of vaccine for animals. It adopts the gene engineering method, clones the gene of muscle somatostatin and expresses the recombined confluence protein of the muscle somatostatin in Escherichia coli or yeast as an immunogen or gene engineering vaccine. Active immunity for growing livestock and birds by the muscle somatostatin engeneering vaccine can promote the animal to generate antibody of the muscle somatostatin, which can neutralize and inhibit the muscle somatostatin produced by self muscle of the livestock and birds, thus absolves the muscle growth inhibiting function of the muscle somatostatin and promotes the muscle growth.

Description

technical field [0001] The invention relates to the field of new technologies for animal husbandry production and veterinary vaccines. Background technique [0002] Promoting muscle growth in agricultural animals has long been a goal pursued by animal production and livestock research institutes. Promoting the muscle growth of livestock and poultry or increasing the lean meat rate not only improves the efficiency of animal feeding, but also produces high-quality and healthy meat, and greatly improves the economic benefits of livestock production. [0003] At present, it mainly promotes muscle growth and increases the speed of livestock and poultry muscle growth through conventional breeding work, adjusting nutrients and nutritional levels. But so far, the muscle growth performance of livestock and poultry under the conventional production and feeding technology has been brought into play to the limit, and the space for promoting muscle growth by t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395C12N15/62C12P19/34
Inventor 施振旦刘颖郭文军
Owner SOUTH CHINA AGRI UNIV
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