Sea anemone neurotoxin gene Sr3 and application thereof
A neurotoxin and sea anemone technology, applied in application, genetic engineering, plant genetic improvement, etc., can solve the problem of less sea anemone neurotoxin, and achieve the effect of prolonging the effective refractory period and enhancing atrial contraction.
Inactive Publication Date: 2005-03-16
SUN YAT SEN UNIV
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At present, there are few domestic research reports on sea anemone neurotoxins
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Abstract
The invention relates to actinocongestin gene Sr3 and its coded protein, and also the uses of the said protein in preparation of drugs for cardiovascular disease. The invention employs RT-PCR method, extracts sequence 1 from total RNA of tentacles of sagartia rosea ( sequence 1 indicates) the protein coded by the gene( sequence 2 indicates) Recombinant actinocongestin protein in the invention has cardiac and anti-arrhythmia action, can prepare the cardiovascular disease drugs.
Description
technical field The invention relates to a sea anemone neurotoxin gene Sr3 and its encoded protein, as well as the application of the protein in the preparation of drugs for treating cardiovascular diseases. Background technique Sea anemone (anthopleura), belonging to coelenterate (soelenterata), coral class (anthozoa), is a relatively primitive animal in the ocean. In the long-term biological evolution process, in order to resist predators and capture food, the nematocysts of sea anemone tentacles can secrete a variety of sea anemone toxins, basically polypeptide toxins, which have various physiological activities on humans and animals. Sea anemone toxins are divided into three categories according to their physiological functions: sea anemone neurotoxins, sea anemone cytolysins, and sea anemone potassium channel inhibitors. Foreign studies on sea anemone neurotoxins began in the 1970s. In 1976, Shibata and others from the University of Hawaii in the United States isola...
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IPC IPC(8): A61K38/17A61P9/00C07K14/44C07K19/00C12N15/10C12N15/30C12N15/70C12P19/34
Inventor 徐安龙陈慧萍王磊董美玲杨文利姜孝玉涂洪斌
Owner SUN YAT SEN UNIV
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