Nano particles of polyglycol-poly(lactide-caprolactone) of carrying camptothecin and preparation method

A polyethylene glycol and nanoparticle technology is applied in the field of preparation of camptothecin nanoparticles, and achieves the effects of simple method, easy-to-obtain raw materials and good redispersion performance

Inactive Publication Date: 2005-06-15
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the use of polyethylene glycol-poly(lactide-capr

Method used

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  • Nano particles of polyglycol-poly(lactide-caprolactone) of carrying camptothecin and preparation method
  • Nano particles of polyglycol-poly(lactide-caprolactone) of carrying camptothecin and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: The molecular weight of monomethoxy-terminated polyethylene glycol is 5000, the weight content is 9%, the molar ratio of lactide / caprolactone is 94 / 6, and the content of stannous octoate is 0.5%.

[0034] 0.5 g of monomethoxy-terminated polyethylene glycol and 4.5 g of lactide were put into a dry flask, vacuumed at 70° C. for 1 hour, 0.0625 g of 0.5 g of caprolactone and 40% stannous octoate in toluene were added, 160 °C for 4 hours.

Embodiment 2

[0035] Example 2: The molecular weight of monomethoxy-terminated polyethylene glycol is 5000, the weight content is 20%, the molar ratio of lactide / caprolactone is 78 / 22, and the content of stannous octoate is 0.5%.

[0036] 0.8 g of monomethoxy-capped polyethylene glycol and 2.24 g of lactide were put into a dry flask, vacuumed at 70° C. for 1 hour, 0.032 g of 0.96 g of caprolactone and 40% stannous octoate in toluene were added, 150 °C for 4 hours.

Embodiment 3

[0037] Example 3: The molecular weight of monomethoxy-terminated polyethylene glycol is 2000, the weight content is 20%, the molar ratio of lactide / caprolactone is 78 / 22, and the content of stannous octoate is 0.8%.

[0038] 1.8 grams of monomethoxy-terminated polyethylene glycol and 2.24 grams of lactide were put into a dry flask, vacuumed at 70°C for 1 hour, 0.10 grams of 0.96 grams of caprolactone and 40% stannous octoate in toluene were added, 150 °C for 4 hours.

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Abstract

A polyethanediol-poly(lactide-caprolactone) nanoparticle carrying camptothecine is prepared from polyethanediol-poly (lactide-caprolactone) as carrier and camptothecine through self-assembling in water. Its advantages are adjustable release speed of caprolactone and high biologic utilization rate.

Description

technical field [0001] The invention belongs to a preparation method of camptothecin nanoparticles, in particular to a preparation method of camptothecin nanoparticles whose carrier is polyethylene glycol-poly-(lactide-caprolactone). Background technique [0002] Campylodendron is a unique plant in my country, widely distributed in various regions south of the Yangtze River, and rich in resources. Camptothecin isolated from camptothecin is a broad-spectrum anticancer drug that is effective against a variety of tumors. The clinical application of camptothecin has proved that it has a good short-term curative effect on malignant tumors such as gastrointestinal adenocarcinoma, choriocarcinoma, acute and chronic myeloid leukemia, and bladder cancer. However, some patients have hematuria, urgency, and frequent urination. side effects, therefore, finding an effective carrier of camptothecin, reducing the toxicity of camptothecin and improving its bioavailability has become one of...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/475A61K47/34A61P35/00
Inventor 张琰杨武利府寿宽汪长春胡建华
Owner FUDAN UNIV
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