Refined puncturevine fruit saponin capable of being administered by injection, its preparing process and injecta

A technology for total saponins of tribulus terrestris and tribulus terrestris, applied in the field of refining terrestris saponins and preparation thereof, can solve problems such as inability to directly prepare intravenous drip preparations, and achieve the effects of enriching administration routes, reducing the limit of harmful impurities and novel dosage forms

Inactive Publication Date: 2005-06-29
吉林敖东洮南药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the total saponins of Tribulus terrestris have significant blood solubility and cannot be directly prepared for intravenous drip preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0635] Take 2.5g of total saponins of Tribulus terrestris, add 90ml of ethanol, reflux for extraction for 40 minutes, filter, add 6.25ml of saturated ethanol solution of β-sitosterol to the filtrate, reflux for 40 minutes, recover ethanol, add water to 25ml, stir well, and place at about 4°C Stand still for 8 hours, filter, heat the filtrate to near boiling, add 0.1g of activated carbon, keep it sealed for 25 minutes, filter, concentrate to about 2.5g, add 7.5ml of acetone under stirring, stand still, pour off the supernatant, the residue The acetone was evaporated and dried under reduced pressure at 80°C for 2 hours. Grind evenly to obtain 1.02g of light yellow powder, the total saponin content of Tribulus terrestris is 81.2%, and the content of furostanol saponin is 72.4%.

Embodiment 2

[0637] Take 2.5g of total saponins of Tribulus terrestris, add 100ml of ethanol, reflux extraction for 30 minutes, filter, add 10ml of stigmasterol saturated ethanol solution to the filtrate, reflux for 40 minutes, recover ethanol, add water to 37.5ml, stir well, and stand at about 4°C After 10 hours, filter, heat the filtrate to near boiling, add 0.1g of activated carbon, keep it sealed for 25 minutes, filter, concentrate to about 2.5g, add 7.5ml of acetone while stirring, let stand, pour off the supernatant, and evaporate the acetone from the residue , dried under reduced pressure at 80°C for 2 hours. Grind evenly to obtain 0.98g of light yellow powder, the total saponin content of Tribulus terrestris is 80.8%, the content of furostanol saponin is 73.2%, and the hemolysis test meets the requirements.

Embodiment 3

[0639] Take 2.5g of total saponins of Tribulus terrestris, add 120ml of ethanol, reflux for extraction for 30 minutes, filter, add mixed phytosterol saturated ethanol solution 7.5ml to the filtrate, reflux for 50 minutes, recover ethanol, add water to 30ml, stir well, and stand at about 4°C. Set aside for 6 hours, filter, heat the filtrate to near boiling, add 0.1g of activated carbon, keep it sealed for 25 minutes, filter, concentrate to about 2.5g, add 7.5ml of acetone under stirring, stand still, pour off the supernatant, and evaporate the residue Remove acetone and dry under reduced pressure at 80°C for 2 hours. Grind evenly to obtain 0.91g of light yellow powder, the total saponin content of Tribulus terrestris is 82.5%, the content of furostanol saponin is 71.8%, and the hemolysis test meets the requirements.

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PUM

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Abstract

The invention discloses a refined puncturevine fruit saponin capable of being administered by injection and its preparing process which comprises, extracting puncturevine saponins through thanol backflow, cooling down, filtrating, charging in alcoholic solution of phytosterin or cholesterol, backflow reacting, decompressing for reclaiming ethanol, watering, freezing, filtrating, charging activated charcoal into the filtrate, stirring, filtering, decompression concentrating the filtrate, charging acetone while stirring, airtight stewing, removing the dissolvent, decompressing, drying and disintegrating.

Description

field of invention [0001] The invention discloses a refined saponin of Tribulus terrestris which can be administered by injection and a preparation method thereof, and also provides a freeze-dried powder injection prepared by using the refined saponin of Tribulus terrestris which can be administered by injection, and is used for preventing and treating ischemic heart and cerebrovascular diseases. The invention relates to diseases, belonging to the technical field of extraction and application of active parts of traditional Chinese medicines. Background technique [0002] Tribulus terrestris involved in the present invention refers to the mature aerial part of Tribulus terrestris L. (hereinafter referred to as: Tribulus terrestris) of Tribulus terrestris L., and the fruit of Tribulus terrestris is a commonly used traditional Chinese medicine "Tribulus terrestris". Based on the fact that Tribulus terrestris and Chinese herbal medicine Tribulus terrestris (fruit) contain very s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61P9/10
Inventor 钱本余沈丽娟赵雪梅耿虹徐飞王国栋刘长胜
Owner 吉林敖东洮南药业股份有限公司
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