Novel effectors of dipeptidyl peptidase IV

A dipeptidyl peptidase and effector technology, applied in the field of new effectors of dipeptidyl peptidase IV, can solve problems such as side effects

Inactive Publication Date: 2005-07-13
PROSIDION LIMITED
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

High levels of inhibitor activity and side effects from long-term use of the same drug can also occur, especially during long-term treatment

Method used

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  • Novel effectors of dipeptidyl peptidase IV
  • Novel effectors of dipeptidyl peptidase IV
  • Novel effectors of dipeptidyl peptidase IV

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Experimental program
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Embodiment Construction

[0030] In the present invention, oral administration of high-affinity low-molecular-weight enzyme inhibitors is an economical alternative to widely used surgical techniques in the treatment of pathological conditions. Through chemical design for stability, transport and clearance properties, the mode of action can be adjusted and adapted to the characteristics of different individuals.

[0031] As mentioned above, for example in the case of long-term treatment of diabetes, it may be necessary to provide effectors with said activity which can meet the different requirements of the patients and treat their symptoms. The said dipeptide compound of the present invention shows that at a (dipeptide compound) concentration of 10 micromolar, especially under the conditions shown in Table 1, dipeptidyl peptidase IV or class DP IV enzyme activity is reduced by at least 10%, especially is at least 40% lower. Usually a reduction of at least 60% or 70% is also required. Preferred effecto...

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Abstract

Valyl-thiazolidide (Ia), valyl-pyrrolidide (Ib), and salts of these, are new.

Description

[0001] This application is a divisional application of Chinese patent application 99806723.7 with the title of "New Effector of Dipeptidyl Peptidase IV" filed on May 28, 1999. technical field [0002] The present invention relates to a dipeptide compound composed of an amino acid and a thiazolidine or pyrrolidinyl group and a compound similar to the dipeptide compound, and a salt thereof, hereinafter referred to as a dipeptide compound, and also relates to the use of the compound in the treatment of glucose in mammals Application in intolerance, diabetes, hyperlipidemia, metabolic acidosis, diabetes, diabetic neuropathy and nephropathy and sequelae of diabetes. [0003] Therefore, the present invention also relates to a simple method for lowering blood glucose concentration in mammals with the aid of dipeptide compounds as activity-reducing effectors (substrates, pseudo-substrates, inhibitors, binding proteins, antibodies, etc.) of enzymes, Said enzyme has similar or the same ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D295/18A61K31/40A61K31/425A61K31/426A61K31/427A61K31/495A61K38/00A61K45/06A61P3/06A61P3/10A61P13/12A61P43/00C07D207/34C07D277/04C07D295/185C07D417/00C07D417/12C07K5/06
CPCA61K31/40A61K31/425A61K31/426A61K31/427A61K45/06C07D277/04C07D295/185A61P1/00A61P13/12A61P3/10A61P3/06A61P43/00A61K2300/00A61K38/05
Inventor 汉斯-乌尔里希·德穆特康拉德·格隆德达格玛·施伦齐希苏珊·克鲁贝尔
Owner PROSIDION LIMITED
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