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Medicinal composition for drug-induced neuropathy

A neurodisease and composition technology, applied in the direction of drug combination, nervous system diseases, sugar derivatives, etc.

Inactive Publication Date: 2005-09-14
YAMASA SHOYU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in which CDP-choline has only been shown to have this possibility, there are no data confirming the efficacy of CDP-choline for peripheral neuropathy

Method used

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  • Medicinal composition for drug-induced neuropathy
  • Medicinal composition for drug-induced neuropathy
  • Medicinal composition for drug-induced neuropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Test compound: Adenosine 5'-diphosphocholine-monosodium salt

[0058] (CDP-choline-Na: manufactured by YAMASA CORPORATION)

[0059] Experiment: Springtail test using vincristine-induced sensory neuropathy mice (in vivo)

[0060] (1) Preparation of mice suffering from vincristine-induced sensory neuropathy

[0061] Vincristine (0.05 mg / kg for the first time, 0.125 mg / kg for the second and subsequent times) dissolved in injected saline was intraperitoneally administered to male ICR strain mice (7-week-old, each group 10 rats), twice a week for 10 weeks, to induce sensory neuropathy.

[0062] (2) Administration of CDP-choline

[0063] CDP-choline·Na was dissolved in distilled water and its administration (500 mg / kg per dose) was started on the same day as vincristine, once a day for 10 weeks.

[0064] (3) Bomb tail test

[0065] The mice were given tail photothermal stimuli, and the response latency after thermal sensation until tail movement was measured.

[0066] C...

Embodiment 2

[0071] Test compound: Adenosine 5'-diphosphocholine-monosodium salt

[0072] (CDP-choline-Na: manufactured by YAMASA CORPORATION)

[0073] Experimental: Springtail test in mice with acrylamide-induced sensory neuropathy (in vivo)

[0074] (1) Preparation of mice with acrylamide-induced sensory neuropathy

[0075] Acrylamide (2.5mg / mouse) dissolved in normal saline was intraperitoneally administered to male ICR strain mice (7-week-old, 10 in each group), 5 times a week for 1 week in total, Induced sensory neuropathy.

[0076] (2) Administration of CDP-choline

[0077] CDP-choline·Na was dissolved in distilled water and its administration (100 mg / kg per dose) was started on the same day as acrylamide, once a day for 10 weeks.

[0078] (3) Bomb tail test

[0079] The mice were given tail photothermal stimuli, and the response latency after thermal sensation until tail movement was measured.

[0080] Control group, the measurement result of the response latency of the acryla...

preparation Embodiment 1

[0084] Formulation Example 1 Tablet

[0085] CDP-choline 30.0mg

[0086] Microcrystalline Cellulose 25.0mg

[0087] Lactose 39.5mg

[0088] Starch 40.0mg

[0089] Talc 5.0mg

[0090] Magnesium stearate 0.5mg

[0091] Tablets are prepared from the above composition by a conventional method.

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Abstract

The present invention relates to an agent for the prophylaxis or treatment of drug-induced neuropathy, which contains cytidine 5'-diphosphocholine (CDP-choline) as an active ingredient. The agent for the prophylaxis or treatment of drug-induced neuropathy of the present invention shows a potent ameliorating effect on drug-induced neuropathy and is also superior in safety.

Description

technical field [0001] The present invention relates to an agent containing cytidine 5'-diphosphocholine (CDP-choline) as an active ingredient for the prevention or treatment of drug-induced neuropathy, including an agent for the prevention or treatment of an effective amount of CDP-choline Or the method for treating said disorder, the application of CDP-choline in the manufacture of a medicament for preventing or treating said disorder, and a pharmaceutical composition for preventing or treating said disorder, the pharmaceutical composition comprising an effective amount of CDP-choline and pharmaceutical carrier. Background technique [0002] Currently, neuropathy such as peripheral neuropathy is known to be induced as a side effect of various drugs. Peripheral nerves induce sensory, motor, and autonomic nerves. If it is disturbed, various symptoms are shown depending on the disturbed area, significantly impairing the patient's quality of life. Therefore, sufficient atte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7068A61P25/00C07H19/10
CPCA61K31/7068C07H19/10A61P25/00A61P25/02
Inventor 远藤和树龟井淳三
Owner YAMASA SHOYU CO LTD