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Method for preparing herb of sowthistle leaf Ixeris injection

A technology of injection preparations and Kudiezi, which is applied in the field of preparation of Kudiezi injection preparations, can solve the problems of high impurity content in the extract, failure to solve the fundamental problem of stability, and no novelty.

Inactive Publication Date: 2005-10-19
张海峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex composition of Kudiezi and the relatively simple extraction and purification process, the extract contained many impurities, resulting in unstable quality of Kudiezi injection, which affected the curative effect of the preparation.
[0003] Patent (Application No. 02109532) "A Traditional Chinese Medicine for Treating Cardiovascular and Fundus Diseases and Its Preparation Method" and Patent (Application No. 03133969) "A Kudiezi Pharmaceutical Preparation and Its Preparation Method" respectively disclose a kind of Kudiezi Powder injection and preparation method, the former is freeze-dried powder injection, and the latter is powder injection made by spray drying method, but the preparation methods of these two inventions basically follow the original Kudiezi injection (WS-10354 (ZD-0354)- 2002) preparation method, no novelty, failed to solve the fundamental problem of stability
Moreover, the semi-finished products are directly fed from the solution, which is not conducive to the quality control and stability of the product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] (1) The raw material medicine is: Kudiezi 1000g.

[0052] (2) Extraction

[0053] Method 1: Take Kudiezi herbs, add 10 times the amount of water to decoct for 1 hour for the first time, and decoct for 0.5 hours with 8 times the amount of water for the second time, combine the decoction liquid, filter, and concentrate until it is equivalent to 0.5 of the original drug per 1ml g's extract.

[0054] Method 2: Take Kudiezi medicinal material, crush it through a 20-mesh sieve, add 6 times the amount of 80% ethanol, 20KHz frequency ultrasonic extraction twice, the first time is 30 minutes, the second time is 20 minutes, the extract is filtered, combined, and the ethanol is recovered under reduced pressure and collected. Concentrate to an extract equivalent to 0.5g of crude drug per 1ml.

[0055] Method 3: Take Kudiezi medicinal material, crush it through a 20-mesh sieve, add 6 times the amount of 95% ethanol to reflux and extract three times, each time for 1 hour, filter th...

Embodiment 2

[0065] (1) The prescription of raw material medicine is: Kudiezi 1000g.

[0066] (2) Extraction

[0067] Method 1: Take Kudiezi herbs, add 12 times the amount of water to decoct for 1 hour for the first time, add 8 times the amount of water to decoct for 0.5 hours for the second time, combine the decoction liquid, filter, and concentrate until it is equivalent to 0.5 of the original drug per 1ml g's extract.

[0068] Method 2: Take Kudiezi medicinal material, crush it through a 30-mesh sieve, add 8 times the amount of 60% ethanol, 20KHz frequency ultrasonic extraction twice, the first time is 30 minutes, the second time is 20 minutes, the extract is filtered, combined, and the ethanol is recovered under reduced pressure and collected. Concentrate to an extract equivalent to 0.5g of crude drug per 1ml.

[0069] Method 3: Take Kudiezi medicinal material, crush it through a 30-mesh sieve, add 8 times the amount of 60% ethanol to reflux and extract three times, each time for 1 h...

Embodiment 3

[0079] (1) The prescription of raw material medicine is: Kudiezi 1500g.

[0080] (2) Extraction

[0081] Method 1: Take Kudiezi herbs, add 10 times the amount of water to decoct for 1 hour for the first time, add 6 times the amount of water to decoct for 0.5 hours for the second time, combine the decoction liquid, filter, and concentrate until it is equivalent to 0.5 of the original drug per 1ml g's extract.

[0082] Method 2: Take Kudiezi medicinal material, crush it through a 40-mesh sieve, add 7 times the amount of 70% ethanol, and extract it twice with 20KHz frequency ultrasound, the first time is 30 minutes, the second time is 20 minutes, the extract is filtered, combined, and the ethanol is recovered under reduced pressure. Concentrate to an extract equivalent to 0.5g of crude drug per 1ml.

[0083] Method 3: Take Kudiezi medicinal material, crush it through a 40-mesh sieve, add 7 times the amount of 80% ethanol to reflux and extract three times, each time for 1 hour, ...

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Abstract

The present invention discloses the preparation process of sowthistle-leaf ixeris injection, and features that purified sowthistle-leaf ixeris extract is first obtained by means of new purification process and then prepared into injection or mixed with medicinal supplementary material and prepared into freeze powder for injection. Pharmaceutical experiment results show that the sowthistle-leaf ixeris injection of the present invention has even high pharmaceutical effect.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a preparation method of Kudiezi injection preparation. Background technique [0002] Kudiezi is the first-year dried whole herb of the Compositae plant, Kudiezi, which has the effects of clearing heat and detoxifying, reducing swelling and relieving pain. Its main components are flavonoid glycosides and adenosine. The preparations now on the market include Kudiezi injection (WS-10354(ZD-0354)-2002). Kudiezi injection has the effects of promoting blood circulation and relieving pain, clearing away heat and removing stasis, and is used for thoracic obstruction caused by blood stasis. numbness, heartache, bitter mouth, dark red tongue or ecchymosis, etc. It is suitable for patients with coronary heart disease and angina pectoris who see the above symptoms, and it can also be used for patients with cerebral infarction. Modern studies have p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61P9/10
Inventor 张海峰
Owner 张海峰
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