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Application of ketosolin in new type analgesic for treatig inflammatory pain

A technology of ketanserin and analgesic, applied in the field of application of ketanserin in new analgesics for treating inflammatory pain

Inactive Publication Date: 2005-10-26
FUJIAN NORMAL UNIV
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  • Claims
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AI Technical Summary

Problems solved by technology

[0013]Kanserin is an oral medicine, and there are also injections. It is only used clinically as an adjuvant treatment of hypertension. So far, no one at home and abroad has used ketanserin used to treat pain

Method used

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  • Application of ketosolin in new type analgesic for treatig inflammatory pain
  • Application of ketosolin in new type analgesic for treatig inflammatory pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Analgesic effect of topical application of "ketanserin patch" on arthritis in rats

[0045] 1 Materials and methods

[0046] 1.1 Reagents and materials

[0047] Carrageenan (US Sigma Company); Keptoserin (Sigma Company); Kaolin (Kaolin China Pharmaceutical Group Shanghai Chemical Reagent Company); Gelatin (Gelatin Tianjin Chemical Reagent Company); CM cellulose sodium salt 800~1200 (CM-Cellulose Na Salt China Pharmaceutical Group Shanghai Chemical Reagent Company); Synthesis of L-camphor (Huangpu Chemical Factory, Guangzhou); Glycerol (Glycerol Shanghai Chemical Reagent Co., Ltd.); Dimethyl Sulfoxide (Dimetyl Sulfoxide, DMSO China Pharmaceutical Group Shanghai Chemical Reagent Company) ; Medical adhesive plaster (Hangzhou Yongninger Pharmaceutical Co., Ltd.).

[0048] Patch preparation method: Adhesive (gelatin, CMC), humectant (glycerol), and excipient (kaolin) were mixed in a ratio of 1:2:1, and ketanserin was weighed according to the severity of the pain. Specific...

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Abstract

An application of ketanserin in preparing the exterior-applied analgesic medicine for treating inflammatory pain is disclosed. Said analgesic medicine is prepared from ketan serin, the adhesive containing gelatin and cellulose sodium CM, the humectant prepared from DMSO and propanetriol, and excipient prepared from kaolinite, levo-camphor and water.

Description

technical field [0001] The present invention belongs to the application invention of new use and new usage of medicine, and specifically relates to a kind of clinically only used as a main component of ketanserin for auxiliary treatment of hypertension, and its application in the preparation of locally applied analgesic medicine for treating pain . Background technique [0002] Pain is a symptom of many patients. Clinically, at least half of the patients seek medical treatment because of pain. Pain causes suffering and suffering to patients, greatly reducing the quality of life; pain weakens people's ability to work, or even completely loses them, which greatly affects people's lives. [0003] To relieve pain and improve the quality of life, pain must be controlled. The treatment of pain is still mainly based on drugs at present. Clinically used analgesics can be divided into two categories: central narcotic analgesics (such as opioid analgesics) and non-narcotic analges...

Claims

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Application Information

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IPC IPC(8): A61K31/517
Inventor 洪炎国
Owner FUJIAN NORMAL UNIV
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