Medicinal composition for treating hepatitis and diabetes

A composition and drug technology, applied in the field of herbal medicine, can solve the problems of providing scientific basis for active ingredients, no clear teaching, no extraction, etc., and achieve the effect of controllable quality, short route and simple operation

Inactive Publication Date: 2005-10-26
昆明生物谷医药研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many chemical research literatures have clearly revealed that the chemical components of Swertia plants are diverse and complex. It is worth noting which active ingredients play a decisive role in the anti-hepatitis and hypoglycemic activities of Swertia, There is no clear teaching in the prior art, and there is no scientific basis for effectively extracting active ingredients

Method used

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  • Medicinal composition for treating hepatitis and diabetes
  • Medicinal composition for treating hepatitis and diabetes
  • Medicinal composition for treating hepatitis and diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation of embodiment 1 purple red water swertia active components (method one)

[0028]Take 25kg of the whole herb of Swertia chinensis, crush it, put it in a stainless steel extraction tank, add 85% alcohol and heat it for 3 times, the amount of alcohol used each time is that the liquid level is submerged and is about 5-10cm higher than the medicinal material, and the first reflux 2 hour, the 2nd and 3rd times were refluxed for 1 hour respectively; the combined alcohol extract was concentrated under reduced pressure to obtain 4.6kg of extract, and the specific gravity was 1.25; 40kg of water was added to the extract, fully stirred, and a large amount of tan precipitate was seen to separate out; filter, Wash the precipitate with water, drain it, dry it in vacuum, grind it finely, use 6 times the amount of petroleum ether to reflux three times to degrease, filter the insoluble part, drain it, and evaporate the solvent to get 0.76kg of yellow-brown powder, which i...

Embodiment 2

[0030] The preparation of embodiment 2 purple red Swertia active components (method two)

[0031] Take 25kg of the whole herb of Swertia chinensis, crush it, put it in a stainless steel extraction tank, add 0.2% NaOH, heat and reflux for extraction 3 times, combine the alkaline water extract, add 10% H 2 SO 4 When the pH value is 2-3, the precipitate is collected by filtration, washed with water, and dried to obtain 0.82 kg of yellow-brown powder, which is the effective component of purple-red Swertia japonicus, with a yield of 3.28%.

Embodiment 3

[0032] Embodiment 3 Assay

[0033] 1. Determination of total ketone content

[0034] Accurately take by weighing 30 mg of the effective components of the purple red Swertia japonica obtained in Example 1, put in a 10ml measuring bottle, add methanol to dissolve and dilute to the mark, shake up; accurately draw 1ml of the solution, put it in a 100ml measuring bottle, add methanol to dilute to the mark, Shake up; according to spectrophotometry, measure the absorbance at the wavelength of 333nm, according to the absorption coefficient (E 1cm 1％ ) for 330 calculations. The content of total ketone in this sample is calculated according to gentio-ketone phenol (C 14 h 10 o 6 ) meter, the measured result is 40.6%.

[0035] 2. Determination of oleanolic acid content

[0036] Accurately weigh 50 mg of the obtained purple swertia oleifera active ingredient and 10 mg of the oleanolic acid reference substance in Example 1, put them in 25 ml measuring bottles respectively, add metha...

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PUM

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Abstract

A composite medicine for treating hepatitis and diabetes is prepared from twospot swertia herb through extracting its active components (oleanolic acid, etc).

Description

Background technique [0001] The invention belongs to the field of herbal medicines, and relates to a preparation method of effective components of Swertia japonica and its application in pharmacy. [0002] There are more than 70 kinds of Swertia plants in my country, of which more than 20 kinds are used to treat liver and gallbladder diseases or other inflammations among the people ("China Traditional Chinese Medicine Resources Chronicle", Science Press, 1974, page 957), and have been commercialized. There are few plant varieties developed. At present, only the gallbladder is recorded in the national standard ("Chinese Pharmacopoeia" 2000 edition, a page 155), and there are other varieties such as Swertia, Swertia grandis, and Southwest Swertia. Included in the local medicinal materials standard (Qian D / WS-208-88), the medicinal materials or patented medicines derived from these Swertia plants are quite distinctive among the existing hepatitis medicines, with definite curative e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56
Inventor 潘锡平林艳和李彪
Owner 昆明生物谷医药研究院有限公司
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