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Paederia powder injection and its preparation method

A technology of chia vine and powder injection, which is applied in the field of chia vine powder injection preparation and its preparation field, can solve the problems such as no report of chia vine powder injection preparation, limited solubilization effect of volatile oil components, and clinical application safety problem.

Inactive Publication Date: 2005-10-26
张海峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the solubilization effect of polysorbate-80 on volatile oil components is very limited, so Jiyateng injection sometimes changes from a colorless and clear solution to a microstrip milky white fluorescent liquid during storage, which brings safety to clinical application. question
[0003] No reports about Jiyateng powder injection preparations have been found in the data search

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Take 20kg of the medicinal material of Ji Yateng, crush it, soak it in water for 1 hour, steam distill, collect the initial distillate of 3 times the weight of the medicinal material, and then redistill, collect the rectified liquid of 1 times the weight of the medicinal material, refrigerate for 7 days, filter, and filtrate Extract twice with 0.5 times the volume of ethyl acetate, collect the ethyl acetate extract, recover ethyl acetate under reduced pressure, dissolve the residue with a small amount of ethanol, slowly add it to a saturated solution made of 20 times the amount of HP-β-CD, Stir at 50°C for 3 hours, then stir at room temperature for another 2 hours, let stand overnight, filter, and dry at low temperature to obtain 2.0 kg of clathrate. Take the clathrate and dissolve it with water for injection, add 1.0 kg of polyvinylpyrrolidone, adjust the pH value to 7.0, filter through a 0.22 μm microporous membrane, dry, and prepare 10,000 powder injection preparation...

Embodiment 2

[0047] Take 20kg of the medicinal material of Ji Yateng, crush it, soak it in water for 1 hour, steam distill, collect the initial distillate of 3 times the weight of the medicinal material, and then redistill, collect the rectified liquid of 1 times the weight of the medicinal material, refrigerate for 7 days, filter, and filtrate Extract 4 times with 0.2 times the volume of ethyl acetate, collect the ethyl acetate extract, recover ethyl acetate under reduced pressure, dissolve the residue with a small amount of ethanol, slowly add it to a saturated solution made of 10 times the amount of HP-β-CD, Stir at 50°C for 3 hours, then stir at room temperature for another 2 hours, let stand overnight, filter, and dry at low temperature to obtain 1.0 kg of clathrate. Take the clathrate and dissolve it with water for injection, add 2.0 kg of mannitol, adjust the pH value to 4.0, filter through a 0.22 μm microporous membrane, and dry to prepare 10,000 powder injection preparations.

Embodiment 3

[0049] Take 20kg of the medicinal material of Ji Yateng, crush it, soak it in water for 1 hour, steam distill, collect the initial distillate of 3 times the weight of the medicinal material, and then redistill, collect the rectified liquid of 1 times the weight of the medicinal material, refrigerate for 7 days, filter, and filtrate Extract 3 times with 0.3 times the volume of ethyl acetate, collect the ethyl acetate extract, recover ethyl acetate under reduced pressure, dissolve the residue with a small amount of ethanol, slowly add it to a saturated solution made of 15 times the amount of HP-β-CD, Stir at 50°C for 3 hours, then stir at room temperature for another 2 hours, let stand overnight, filter, and dry at low temperature to obtain 1.6 kg of clathrate. Take the clathrate and dissolve it with water for injection, add 1.4kg of glucose, adjust the pH value to 5.0, filter through a 0.22 μm microporous membrane, freeze-dry, and prepare 10,000 tubes of freeze-dried powder prep...

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PUM

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Abstract

A Chinese medicine in the form of powder injection for dispelling the exogenous factor of wind and acesodyne is prepared from Chinese fevervine through extracting its volatile oil, mixing with HP-beta-CD, mixing with medicinal auxiliary, etc.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a jaggery powder injection preparation and a preparation method thereof. Background technique [0002] Chicken arrow vine Herba Paederiae is madder feed chicken arrow rattan plant. It has been reported in the literature that Jiyateng injection, which is distilled twice from the medicinal material Jiyateng, has good analgesic effects on various types of abdominal pain, pain caused by cancer, dysmenorrhea, postoperative pain, and headache caused by chemical factors; It also has a certain effect on pain in the liver area, pain caused by urinary system diseases, toothache, and traumatic pain. In the preparation process of Jiyateng Injection, two distillations are used, and the saturated aqueous solution of volatile oil is finally collected. Due to the low solubility of volatile oil in aqueous solution, polysorbate-80, a solubilizer, was add...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 张海峰
Owner 张海峰