Application of fraxiketone as medicine for treating liver disease

A technology for the treatment of drugs and ketones, applied in the pharmaceutical field, can solve the problems of little research and so on

Inactive Publication Date: 2006-01-25
徐强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Since the chemical structure of Fraxinellone was reported, there has been little research on this compound, and there have been no r

Method used

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  • Application of fraxiketone as medicine for treating liver disease
  • Application of fraxiketone as medicine for treating liver disease
  • Application of fraxiketone as medicine for treating liver disease

Examples

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Example Embodiment

[0038] 1. From the root bark of Dictamnus dasycorpus Turcz. Take 9.0 kg of white fresh peel coarse powder, extract with ethanol, extract with petroleum ether, and eluted by chromatography to obtain 3.5 g of ketone. Choketones can also be isolated from other plants or obtained by chemical synthesis.

[0039] 2. For CCl 4 Induced acute liver injury in mice, oral administration of 10 mg / kg of ketone can significantly reduce the increase in AST activity caused by liver injury. Both 20 and 40 mg / kg of ketone can significantly inhibit the activity of ALT and AST in a dose-dependent manner. .

[0040] 3. For D-GalN and LPS-induced liver injury, ketone 10 and 20 mg / kg can significantly reduce the increased AST activity, and have a tendency to inhibit the increase of ALT activity. 40mg / kg of linketone can significantly reduce the activity of elevated ALT and AST, and the three dose groups of linketone can improve the mortality of mice with liver injury.

[0041] 4. For CCl 4 Causes chronic...

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Abstract

The invention relates to the use of Fraxinellone as medicament for treating hepatic diseases, wherein the Fraxinellone is separated from the velamen of Dictamnus dasycorpus Turcz, the Fraxinellone can substantially improve acute hepatic injury in mouse induced with CCl4, D-galactosamine and lipopolysaccharide, in addition, the Fraxinellone can substantially inhibit the release of glutamate-pyruvate transaminase in CCl4 induced mouse primary culture hepatocytes injuries, thus can be used as a novel medicament for treating hepatic diseases.

Description

1. Technical field [0001] The invention belongs to the technical field of pharmacy. 2. Background technology [0002] Since the chemical structure of Fraxinellone was reported, there have been few studies on this compound, and there have been no reports about its pharmacological activities, especially the effects of protecting the liver, reducing enzymes, and anti-fibrosis of the liver. The present invention mainly finds that arketone can significantly improve various acute and chronic liver injuries. 3. Contents of the invention [0003] The purpose of the present invention is to study the effect of alkone in the treatment of various acute and chronic viral hepatitis, chemical hepatitis, alcoholic hepatitis, drug-induced hepatitis, severe hepatitis, fulminant liver failure, fatty liver, liver fibrosis, liver cirrhosis and other liver diseases. application in related diseases. [0004] Technical scheme of the present invention [0005] 1. Extraction, separation and stru...

Claims

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Application Information

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IPC IPC(8): C07D307/83A61K31/365A61P1/16A61P31/14
Inventor 徐强吴斐华朱丹妮陈婷
Owner 徐强
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