Injection for treating acute cholecystitis and method for preparing the same

A technology for acute cholecystitis and injections, which is applied in the field of preparation of the gallbladder-clearing injections to achieve the effects of rapid action, avoiding secondary pollution, and high bioavailability

Inactive Publication Date: 2006-02-08
成都百康医药工业药理毒理研究院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to: aim at the existing problems of traditional Chinese medicine preparations for the treatment of acute cholecystitis, and provide a kind of intravenous Chinese medicine com

Method used

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  • Injection for treating acute cholecystitis and method for preparing the same
  • Injection for treating acute cholecystitis and method for preparing the same
  • Injection for treating acute cholecystitis and method for preparing the same

Examples

Experimental program
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Effect test

Embodiment 1

[0065] Embodiment 1: the preparation of freeze-dried powder injection

[0066] (1) Take 50kg of gardenia medicinal material and crush it into coarse granules, extract 3 times with 80% ethanol, extract 2 hours with 10 times the amount for the first time, extract 1.5 hours with 8 times the amount for the second time, and extract with 6 times the amount for the third time Quantitative extraction for 1 hour. Combine the extracts, slowly pass through a chromatographic column equipped with 1.5kg of activated carbon, collect the ethanol liquid, recover the ethanol and concentrate it to a clear paste with a relative density of about 1.20 (60°C), add 10 times the amount of water, let it stand, and refrigerate for 24 hours. Filter, the filtrate is concentrated to about 100L, filter, the filtrate is passed through the D 101 Macroporous adsorption resin column, add 750L of water to elute, discard the aqueous solution, continue to elute with 700L of 30% ethanol, collect the 30% ethanol el...

Embodiment 2

[0069] Embodiment 2: the preparation of small volume injection

[0070] Get 40g of Gardenia jasminoides extract (in terms of total gardenia glycosides) under Example 1, add 2000ml of water for injection to dissolve, and set aside; get 20g of Scutellaria baicalensis extract (in terms of baicalin), add 500ml of water for injection, add 10% Dissolve 37.5ml of sodium hydroxide solution and set aside; combine the liquid medicines, heat to boil, add 20g of activated carbon, stir well, boil for 30 minutes, filter, add water for injection to the filtrate to 5000ml, adjust the pH value to 6.8, fine filter, and pack Make 500 vials in 10ml ampoules, melt seal, sterilize, check clarity, pack, and get ready.

Embodiment 3

[0071] Embodiment 3: the preparation of large volume sodium chloride injection

[0072] Get 80g of Gardenia jasminoides extract (in terms of total gardenia glycosides) under Example 1, add 20000ml of water for injection to dissolve, and set aside; get 40g of Scutellaria baicalensis extract (in terms of baicalin), add 7500ml of water for injection, add 10% Dissolve 75ml of sodium hydroxide solution and set aside; take 760g of sodium chloride for injection, 150g of sodium bisulfite, and 150g of sodium citrate, add 10,000ml of water for injection to dissolve, combine with the above liquid, heat to boil, add 30g of activated carbon, Stir well, boil for 30 minutes, filter, add water for injection to the filtrate to 100000ml, adjust the pH value to 6.8, fine filter, divide into 100ml infusion bottles, make 1000 bottles, cap, sterilize, check the clarity, pack , that is.

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Abstract

The invention relates to a Chinese medicinal compound injection for treating acute cholecystitis, which mainly comprises the extracts of traditional Chinese herbs of cape jasmine and baikal skullcap root, which are cape jasmine glycosides and baikal skullcap root glycosides. The invention also relates to the process for preparing the injection.

Description

technical field [0001] The present invention relates to a traditional Chinese medicine compound effective part injection for treating acute cholecystitis, in particular to a method of extracting and separating effective parts of gardenia extract (gardenia total glycosides) and scutellaria baicalensis extract (scutellaria baicalensis) by using gardenia and scutellaria baicalensis as raw materials. The gallbladder-clearing injection for intravenous injection prepared in combination with glucoside), and the present invention also relates to the preparation method of the gallbladder-clearing injection. Background technique [0002] In recent years, the incidence of acute cholecystitis has been increasing year by year, and has become the most common biliary system disease. The disease usually has a rapid onset, and the lesion site is unbearably painful, which brings great suffering to patients. For the treatment of acute cholecystitis, anti-inflammatory and choleretic drugs are u...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K36/539A61K9/08A61P1/16
Inventor 杨奎张良
Owner 成都百康医药工业药理毒理研究院
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