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Process for producing neogenetic bovine serum of bovine virus diarrhea virus anti-body negativity for producing swine fever vaccine

A technology of newborn bovine serum and swine fever vaccine, which is applied in the production process of swine fever vaccine production/BVDV antibody negative newborn bovine serum, can solve the problems of inability to achieve BVDV antibody negativity and high BVDV antibody positive rate, and achieves low cost and high results. Reliable, quality-enhancing results

Inactive Publication Date: 2006-03-22
兰州民科生物技术中心
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AI Technical Summary

Problems solved by technology

Because the positive rate of BVDV antibody in cattle herds is high, it is impossible to achieve negative BVDV antibody in the serum of finished newborn cattle. This reality has long plagued the manufacturers and users of swine fever vaccine. This is also the biggest obstacle to improving the quality and efficiency of swine fever vaccine.

Method used

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Examples

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Effect test

Embodiment Construction

[0007] For healthy calves born within 14 hours (it must be ensured that the time from birth to blood collection must not exceed 14 hours) that have passed the quarantine and have not eaten colostrum in the non-epidemic area, establish a health file that is conducive to traceability of the cow. The content of the file mainly includes the location (breeding Farm), animal owner, serial number and recent epidemic prevention situation. Classify and number the calves according to their health status and birth time. Healthy calves born within 2 hours are indicated by a green card (F), and those acquired on the same day are indicated by F1, F2, F3.... Healthy calves born within 4 hours are indicated by a blue card (G), and those acquired on the same day are indicated by G1, G2, G3.... Healthy calves born more than 14 hours ago are indicated by a yellow card (Y), and those acquired on the same day are indicated by Y1, Y2, Y3.... Calves that are depressed, loose or eating are indicate...

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Abstract

The present invention relates to production process of neogenetic bovine serum, and is especially the production process of neogenetic bovine serum of BVDV antibody negativity for producing swine fever vaccine. The production process includes the steps of closed bacteria-free blood collection, letting stand to solidify, low temperature separation, screening BVDV antibody negativity serum, mixing, and membrane filtering. The present invention has the advantages of high production efficiency, high reliability, low cost, high swine fever vaccine quality, etc.

Description

technical field [0001] The present invention relates to a newborn bovine serum production process, more specifically, relates to a production of swine fever vaccine / BVDV antibody negative newborn bovine serum production process. Background technique [0002] Newborn bovine serum is a light yellow, clear and slightly viscous supernatant made from blood collected from healthy calves that have not eaten within 14 hours of birth, collected by separation, filtered and sterilized. (such as swine fever vaccine) one of the indispensable raw materials. At present, the production process of BVDV antibody-negative newborn bovine serum for the production of swine fever vaccine is as follows: After cleaning the body surface of healthy newborn calves that have not eaten colostrum within 14 hours after birth, they are fixed on the blood collection table, and after blood collection, separation, mixing, Filtration and other processes. Due to the high positive rate of BVDV antibody in the c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/16A61K39/187A61P31/12
Inventor 马忠仁侯兰新乔自林冯玉萍冯若飞李明生王茂林
Owner 兰州民科生物技术中心
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