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Solasodine hydriodate and its preparation method and its uses in medicine

A technology of solanamine hydroiodide and medicinal residues, which is applied in the field of preparation of Australian solanamine hydroiodide, and can solve the problems that the related information of Australian solanamine hydroiodide has not yet been found.

Inactive Publication Date: 2006-04-26
刘芯辰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Existing domestic and foreign solanum solanum, Australian solanum and yellow fruit solanum chemical constituents, Australian solanamine, Australian solanamine hydrochloride, Australian solanamine sulfate, Australian solanamine organic acid salt and its extraction and preparation method and its application in medicine Applied patents and reports, but no relevant information about Australian solanamine hydroiodide has been found

Method used

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  • Solasodine hydriodate and its preparation method and its uses in medicine
  • Solasodine hydriodate and its preparation method and its uses in medicine
  • Solasodine hydriodate and its preparation method and its uses in medicine

Examples

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Effect test

Embodiment 1

[0058] Example 1 Preparation of Australian solanamine hydroiodide with Solanum nigrum as raw material

[0059] With reference to Fig. 1, take nightshade fruit as raw material to prepare Australian solanamine hydroiodide, the preparation method is as follows:

[0060] (1) Take by weighing 1000kg of Solanum nigrum fruit harvested in late September, remove sundries, and pulverize solid-liquid separation with a refiner to obtain medicinal juice and medicinal residues. The dregs are leached twice with 1% hydrochloric acid aqueous solution, the solid-liquid ratio is 1:1, and the solid-liquid separation is obtained with a refiner. Combine the concoction and the infusion, leave it to settle, take the supernatant and filter, add 20% NaOH aqueous solution to pH7.5 when the filtrate is heated to 80°C, and then add (NH 4 ) 2 CO 3 Saturate the aqueous solution to pH 8, cool and settle, remove the supernatant, and centrifuge the turbid liquid to obtain the paste-like crude total alkaloid...

Embodiment 2

[0063] Example 2 Preparation of Australian solanamine hydroiodide with yellow fruit eggplant as raw material

[0064] With reference to Fig. 1, preparation method is as follows:

[0065] (1) Take by weighing 1000kg of huangguoqie fruits harvested in late September, remove sundries, and pulverize with a refiner for solid-liquid separation to obtain medicinal juice and medicinal residues. The medicinal dregs are leached twice with 3% formic acid aqueous solution, the solid-liquid ratio is 1:1, and the solid-liquid separation is obtained with a refiner. Combine the medicinal juice and infusion, place it for sedimentation, take the supernatant and filter it, and add Ca(OH) when the filtrate is heated to 80°C 2 After the saturated aqueous solution reaches pH7.5, add (NH 4 ) 2 CO 3 Saturate the aqueous solution to pH 8, cool and settle, remove the supernatant, and centrifuge the turbid liquid to obtain the paste-like crude total alkaloids.

[0066] (2) Dissolve the crude total ...

Embodiment 3

[0068] Example 3 Preparation of Australian solanamine hydroiodide with Australian solanum fruit as raw material

[0069] With reference to Fig. 1, preparation method is as follows:

[0070] (1) Weigh 1000kg of Australian eggplant fruits harvested in late September, remove foreign matter, and pulverize with a refiner for solid-liquid separation to obtain medicinal juice and medicinal residues. The medicinal dregs were leached twice with 4% acetic acid aqueous solution, the solid-liquid ratio was 1:1, and the solid-liquid separation was obtained by a refiner. Combine the medicinal juice and infusion, place it for sedimentation, take the supernatant and filter it, and add Ca(OH) when the filtrate is heated to 80°C 2 After saturating the solution to pH 7.5, add (NH 4 ) 2 CO 3 Saturate the aqueous solution to pH 8, cool and settle, remove the supernatant, and centrifuge the turbid liquid to obtain the paste-like crude total alkaloids.

[0071] (2) Dissolve the crude total alka...

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PUM

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Abstract

The present invention provides one new kind of compound, solasodine hydriodide, with obvious anticancer and asthma relieving effects, less toxic side effect, stable property and high dissolubility. The molecular expression is shown. The present invention also relates to the preparation process of solasodine hydriodide with black nightshade, Australia eggplant or yellowfruit nightshade as material. The preparation process includes acid leaching and precipitating to obtain total alkaloid. The preparation process of the present invention has low reagent cost, no environmental pollution, short production period, high product purity and other advantages. The present invention also relates to the application of solasodine hydriodide in preparing medicine for treating cancer and relieving asthma, etc.

Description

technical field [0001] The present invention relates to a compound with anti-cancer and anti-asthma activities, solanamine hydroiodide, a preparation method of solanamine hydroiodide and a new drug source using solanamine hydroiodide as a class of new drugs. Anti-cancer, anti-asthma and other medical applications. Background technique [0002] Existing domestic and foreign solanum solanum, Australian solanum and yellow fruit solanum chemical constituents, Australian solanamine, Australian solanamine hydrochloride, Australian solanamine sulfate, Australian solanamine organic acid salt and its extraction and preparation method and its application in medicine Application patents and reports, but no relevant information on Australian solanamine hydroiodide has been found. Contents of the invention [0003] The present invention provides a kind of Australian solanamine hydroiodide with strong anti-cancer and anti-asthma activit...

Claims

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Application Information

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IPC IPC(8): C07J71/00A61K31/58A61P11/06A61P35/00
Inventor 刘良刘芯辰崔淑华
Owner 刘芯辰
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