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Solasodine hydrofluoric acid salt and its preparation method and its uses in medicine

A technology of solanamine hydrofluoride and medicinal residues, which is applied in the field of preparation of Australian solanamine hydrofluoride, and can solve the problem that the relevant information of Australian solanamine hydrofluoride has not yet been found.

Inactive Publication Date: 2008-02-13
刘芯辰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At home and abroad, there are chemical components of black nightshade, solanum solanum and solanum solanum, solanamine solanum, solanamine hydrochloride, solanamine sulfate, solanamine organic acid salt and their preparation methods and their application in medicine patents and reports, but no relevant information about Australian solanamine hydrofluoride has been found

Method used

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  • Solasodine hydrofluoric acid salt and its preparation method and its uses in medicine
  • Solasodine hydrofluoric acid salt and its preparation method and its uses in medicine
  • Solasodine hydrofluoric acid salt and its preparation method and its uses in medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1 prepares Australian solanamine hydrofluoride with Solanum nigrum as raw material

[0053] With reference to Fig. 1, take nightshade fruit as raw material to prepare Australian solanamine hydrofluoride, the preparation method is as follows:

[0054] (1) Take by weighing 1000kg of Solanum nigrum fruit harvested in late September, remove sundries, and pulverize solid-liquid separation with a refiner to obtain medicinal juice and medicinal residues. The dregs are leached twice with 1% hydrochloric acid aqueous solution, the solid-liquid ratio is 1:1, and the solid-liquid separation is obtained with a refiner. Combine the concoction and the infusion, leave it to settle, take the supernatant and filter, add 20% NaOH aqueous solution to pH 7.5 when the filtrate is heated to 80°C, and then add (NH 4 ) 2 CO 3 Saturate the aqueous solution to pH 8, cool and settle, remove the supernatant, and centrifuge the turbid liquid to obtain the paste-like crude total alkalo...

Embodiment 2

[0057] Embodiment 2 prepares Australian solanamine hydrofluoride with yellow fruit eggplant as raw material

[0058] With reference to Fig. 1, preparation method is as follows:

[0059] (1) Take by weighing 1000kg of huangguoqie fruit harvested in late September, remove sundries, and pulverize with a refiner for solid-liquid separation to obtain medicinal juice and medicinal residues. The medicinal dregs are leached twice with 3% formic acid aqueous solution, the solid-liquid ratio is 1:1, and the solid-liquid separation is obtained with a refiner. Combine the concoction and infusion, set aside to settle, take the supernatant and filter, add 20% NaOH aqueous solution to pH 7.5 when the filtrate is heated to 80°C, and then add NH to the hot solution 4 HCO 3 Saturate the aqueous solution to pH 8, cool and settle, remove the supernatant, and centrifuge the turbid liquid to obtain the paste-like crude total alkaloids.

[0060] (2) Dissolve the crude total alkaloids with 3% form...

Embodiment 3

[0062] Embodiment 3 prepares Australian solanamine hydrofluoride with Australian solanum fruit as raw material

[0063] With reference to Fig. 1, preparation method is as follows:

[0064] (1) Weigh 1000kg of Australian eggplant fruits harvested in late September, remove foreign matter, and pulverize with a refiner for solid-liquid separation to obtain medicinal juice and medicinal residues. The medicinal dregs were leached twice with 4% acetic acid aqueous solution, the solid-to-liquid ratio was 1:1, and the solid-liquid separation was obtained with a refiner. Combine the medicinal juice and infusion, place it for sedimentation, take the supernatant and filter it, and add Ca(OH) when the filtrate is heated to 80°C 2 After the saturated aqueous solution reaches pH 7.5, add (NH 4 ) 2 CO 3 Saturate the aqueous solution to pH 8, cool and settle, remove the supernatant, and centrifuge the turbid liquid to obtain the paste-like crude total alkaloids.

[0065] (2) Dissolve the ...

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Abstract

The present invention provides one new kind of compound, solasodine hydronfluoride, with obvious anticancer and asthma relieving effects, less toxic side effect, stable property and high dissolubility. The molecular expression is shown. The present invention also relates to the preparation process of solasodine hydronfluoride with black nightshade, Australia eggplant or yellowfruit nightshade as material. The preparation process includes acid leaching and precipitating to obtain total alkaloid. The preparation process of the present invention has low reagent cost, no environmental pollution, short production period, high product purity and other advantages. The present invention also relates to the application of solasodine hydronfluoride in preparing medicine for treating cancer and relieving asthma, etc.

Description

technical field [0001] The present invention relates to a compound thalaminamine hydrofluoride having anticancer and antiasthma activities, a preparation method of solanamine hydrofluoride and a new drug source using solanamine hydrofluoride as a class of new drugs Application in anti-cancer, anti-asthma and other medicines. Background technique [0002] At home and abroad, there are chemical components of Solanum solanum, Solanum solanum and Solanum solanum, Solanamine solanum, Solanamine hydrochloride, Solanamine sulfate, Solanamide organic acid salt and their preparation methods and their application in medicine Patents and reports, but no relevant information about Australian solanamine hydrofluoride has been found. Contents of the invention [0003] The present invention provides an anti-cancer, anti-asthma active, less toxic and side effects, stable properties, good solubility, simple preparation process and preparation method of Australian solanamine hydrofluoride ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J71/00A61K31/58A61P35/00A61P11/06
Inventor 刘良刘芯辰崔淑华
Owner 刘芯辰
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