Antibody vaccine conjugates and uses therefor
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- CELLDEX THERAPEUTICS INC
- Publication Date
- 2006-05-03
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
[0001] related application
[0002] This application claims priority to US Provisional Patent Application Serial No. 60 / 443,979, filed January 31,2003. The entire contents of the aforementioned applications are incorporated herein by reference. Background of the invention
[0003] The immune response is initiated at the level of professional antigen-presenting cells (APCs), which include dendritic cells (DCs) and macrophages (Mgs) present in body tissues. DCs express high levels of cell surface molecules and complement receptors that interact with T lymphocytes, thereby inducing potent immune responses. DCs also secrete cytokines, chemokines, and proteases that initiate the immune response and culminate in the amplification of both cellular and humoral immunity.
[0004] DCs express major histocompatibility complex (MHC) molecules on their surface that bind antigen fragments. T cells expressing T cell receptors (TCRs) that recognize such antigen-MHC complexes become activat...