Unlock instant, AI-driven research and patent intelligence for your innovation.

Devices and methods for delivering electrical signals to modify gene expression in cardiac tissue

A technology of heart tissue and gene expression, applied in electrotherapy, cardiac stimulators, internal electrodes, etc., can solve the problems of chronic improvement and reconstruction of left ventricular function, and achieve the effect of improving heart function

Active Publication Date: 2015-12-16
IMPULSE DYNAMICS NV
View PDF20 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Previously, it has been shown that in dogs with heart failure, non-excitatory cardiac contractility modulation (CCM) electrical signals are delivered to the left ventricular muscle during the absolute refractory phase, resulting in left ventricular function chronic improvement and reconstruction of

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Devices and methods for delivering electrical signals to modify gene expression in cardiac tissue
  • Devices and methods for delivering electrical signals to modify gene expression in cardiac tissue
  • Devices and methods for delivering electrical signals to modify gene expression in cardiac tissue

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] In one study, we investigated whether 4 hours of continuous treatment with cardiac contractility modulation (CCM) signals from the OPTIMIZER-IIETC device (available from ImpulseDynamics) could improve the Normalization of gene expression of A and B natriuretic peptides in LV myocardium. During thoracotomy preparation, the CCM lead was implanted on the anterior surface of the LV.

[0087] The signal parameters used were: CCM voltage of 3-7.5 V, 2-4 biphasic pulse trains delivered per beat, total duration of 20-35 ms, and a delay of up to 100 ms from local electrical activity. Although these parameter settings are sufficient to produce the desired effect, we believe that other pulse parameters can also achieve this effect.

[0088] A total of 3 dogs were examined. LV tissues from 3 normal (NL) dogs and 3 untreated HF dogs were used for comparison. LV tissue obtained at sacrifice was used to extract total RNA. Type B and type A natriuretic peptides were identified on a...

Embodiment 2

[0094] In another example, we investigated whether 4 hours of continuous treatment with cardiac contractility modulation (CCM) signals from the OPTIMIZER-IIETC device could restore bFGF gene expression in dogs with HF due to coronary microembolism. CCM therapy has previously been shown to improve LV ejection fraction (EF) in dogs with HF. During thoracotomy preparation, the CCM lead was implanted on the anterior surface of the LV. Set the CCM signal parameters to the same values ​​as described in Example 1 above. A total of 3 dogs were examined. LV tissues from 3 normal (NL) dogs and 3 untreated HF dogs were used for comparison. LV tissue obtained at sacrifice was used to extract total RNA. bFGF was measured by restriction enzyme analysis using specific primers in reverse transcriptase-polymerase chain reaction (RT-PCT) and RT-PCR products, and bands were quantified in optical density units. The results are shown in the table below.

[0095] Table 2

[0096]

[0097...

Embodiment 3

[0100] In a further experiment, we investigated whether 4 hours of continuous treatment with cardiac contractility modulation (CCM) signals from an OPTIMIZER-IIETC device could restore αMHC gene expression in dogs with HF caused by coronary microembolism . CCM therapy has previously been shown to improve LV ejection fraction (EF) in dogs with HF. During thoracotomy preparation, a CCM lead is implanted on the anterior surface of the LV. The CCM signal parameters were set to the same values ​​as described in Embodiment 1 above. A total of 3 dogs were examined. LV tissues from 3 normal (NL) dogs and 3 untreated HF dogs were used for comparison. LV tissue obtained at sacrifice was used to extract total RNA. αMHC was measured by using specific primers in reverse transcriptase-polymerase chain reaction (RT-PCT), and restriction enzyme analysis of RT-PCR products, and bands were quantified in optical density units. The results are shown in the table below.

[0101] table 3

...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Methods and apparatus (120) for modifying gene expression in cardiomyocytes (110) by applying an electric field.

Description

[0001] Cross-References to Related Applications [0002] This application is based on, and claims the benefit of, U.S. Provisional Patent Application 60 / 453,349, filed March 10, 2003, and U.S. Provisional Patent Application 60 / 503,075, filed September 10, 2003, under 35USC119(e), at The entire contents of their disclosures are hereby incorporated into this application by reference. field of invention [0003] The present invention relates to the field of myocardial control. In certain embodiments, the invention relates to the use of electrical signals to treat heart failure and / or other diseases by modifying gene expression. Background of the invention [0004] Heart failure affects (and / or may result from) a variety of mechanisms involved in heart function. Among these mechanisms, the expression of certain genes may be affected, causing them to be suppressed or overexpressed, which affects the function of the cell and the muscle as a whole. The expression of multiple gen...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61N1/00A61N1/32A61N1/362
CPCA61N1/0587A61N1/326A61N1/3627A61N1/36557A61P9/04
Inventor 尤瓦尔·米卡哈尼·萨巴瓦利德·哈达德本尼·鲁索
Owner IMPULSE DYNAMICS NV
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com