Monoclonal antibody ZUB1 of human bone marrow mesenchymal stem cells and application thereof

A monoclonal antibody, bone marrow mesenchymal technology, applied in the biological field, can solve the problems of lack of understanding, monospecific labeling, etc.
CN1803844AInactive Publication Date: 2006-07-19ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2006-07-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a ZUB1 as monoclonal antibody prepared with mesenchyme stem cell in human marrow as antigen by hybridoma technique, and creates the detection method with ZUB1 as probe for mesenchyme stem cell by flow cytometry, immunohistochemistry, immunofluorescence staining, and immunoblotting. This invention provides an effective tool for mesenchyme stem cell research both in specific label and its biological specificity, even more application.
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Description

Technical field:

[0001] The invention belongs to the field of biological technology, and relates to anti-human bone marrow mesenchymal stem cell monoclonal antibody ZUB1 and its application. Background technique:

[0002] Mesenchymal Stem Cells (Mesenchymal Stem Cells, Mesenchymal Stem Cells) is a hotspot in the field of adult stem cell research in recent years, which can be isolated from bone marrow, umbilical cord blood, adipose tissue, synovium, skeletal muscle, lung, and deciduous teeth. Potential to divide, proliferate, and differentiate into various cells. Under certain in vivo or in vitro induction conditions, it can differentiate into cells of various germ layers, such as adipocytes, chondrocytes, osteoblasts, tenocytes, muscle cells, and astrocytes. Cells, neuron cells, epithelial cells, etc.; mesenchymal stem cells have weak immunogenicity, do not express MHC-II molecules and T cell co-stimulatory molecules, and have immunomodulatory activity, which makes the appli...

Claims

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