Multi-layer tablet containing calsium-path receptor retarder and ACE inhibitor, and preparing method

A receptor blocker and calcium channel technology, applied in the field of preparing the multi-layer tablet, can solve the problems of insecurity, the enlargement of the capsule shell, the size limitation of the capsule shell, etc., and achieves simple preparation, stable quality and rapid disintegration. Effect

Inactive Publication Date: 2006-08-09
SUZHOU DAWNRAYS PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of such capsules requires special equipment, and is limited by the size of the capsule shell, so it is generally only suitable for low-dose main drugs
When a large dose is required, the capsule shell beco...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] 2.5mg of levamlodipine and 10mg of benazepril hydrochloride to prepare double-layer tablets--10000 tablets of levamlodipine sheet-layer prescription

[0057] Raw material name dosage

[0058] Levoamlodipine besylate (calculated as levamlodipine) 25g

[0059] Calcium hydrogen phosphate 312g

[0060] Microcrystalline Cellulose 720g

[0061] Sodium carboxymethyl starch 120g

[0062] Magnesium Stearate 12g

[0063] Benazepril tablet prescription

[0064] Raw material name dosage

[0065] Benazepril Hydrochloride 100g

[0066] Microcrystalline Cellulose 300g

[0067] Lactose 470g

[0068] Croscarmellose Sodium 50g

[0069] Povidone 2g

[0070] Brilliant blue aluminum lake 0.04g

[0071] Pure water 38g

[0072] Hydrogenated Castor Oil 50g

[0073] Preparation Process:

[0074] Levoamlodipine sheet layer raw material mixing

[0075] (1) Pass the levamlodipine raw material through a 100-mesh sieve.

[0076] (2) Dibasic calcium phosphate, microcrystalline cellulo...

Embodiment 2

[0089] 5mg amlodipine and 10mg benazepril double-layer tablet, prescribed for 10000 amlodipine tablet

[0090] Raw material name dosage

[0091] Amlodipine besylate (calculated as amlodipine) 50g

[0092] Calcium hydrogen phosphate 450g

[0093] Microcrystalline Cellulose 900g

[0094] Sodium carboxymethyl starch 160g

[0095] Magnesium Stearate 16g

[0096] Benazepril tablet prescription

[0097] Raw material name dosage

[0098] Benazepril Hydrochloride 100g

[0099] Microcrystalline Cellulose 450g

[0100] Lactose 700g

[0101] Croscarmellose Sodium 70g

[0102] Povidone 2.5g

[0103] Brilliant blue aluminum lake 0.05g

[0104] Pure water 50g

[0105] Hydrogenated castor oil 80g

[0106] Preparation Process:

[0107] Amlodipine sheet layer raw material mixing

[0108] (1) Pass the amlodipine besylate raw material through a 100-mesh sieve.

[0109] (2) Dibasic calcium phosphate, microcrystalline cellulose, sodium carboxymethyl starch and magnesium stearate ar...

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PUM

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Abstract

This invention is a multilayer tablet contains calcium channel acceptor retarder and ACE inhibitor. Its feature is that it contains calcium channel acceptor retarder pleated sheet and ACE inhibitor pleated sheet. The calcium channel acceptor retarder pleated sheet contains levamlodipine or amoldipine or salt that can be accepted on pharmacy of them. The ACE inhibitor pleated sheet contains methylphenidate or its pharmacy accepted salt. They can be produced by normal medicine equipment, and preparation is easy, the multilayer tablet made can be quickly disintegrated, main medicine component can be quickly stripped, and its quality stability is good.

Description

technical field [0001] The present invention relates to a multi-layer tablet, which contains the calcium channel receptor blocker amlodipine or levoamlodipine sheet and the ACE inhibitor benazepril sheet, and the invention also provides the preparation of the multi-layer tablet Methods. Background technique [0002] Amlodipine (Amlodipine) is the third generation of dihydropyridine calcium antagonists, which began to be used clinically in the 1990s. In addition to its good antihypertensive effect, it also has a unique anti-atherosclerotic effect. After binding to the receptor, the dissociation speed is slow, the effect appears later and lasts longer, and the selectivity to blood vessels is higher than that of nifedipine. Unlike other calcium channel receptor blockers, amlodipine has no effect on myocardial conduction and contractility, so reflex tachycardia does not occur, and is suitable for the treatment of various types of hypertension and stabl...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K9/20A61K31/4422A61K31/55A61P9/12A61P3/10
Inventor 初虹马成孝
Owner SUZHOU DAWNRAYS PHARM CO LTD
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