Domperidone drip pills and its preparation method

A technology of dipperidone dripping pills and domperidone, which is applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as low qualified product rate, reduced product qualified rate, and reduced practicability, and achieve drug use Accurate amount, small difference in pellet weight, and low production cost

Inactive Publication Date: 2006-08-30
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The application number is that the Chinese invention patent of 200310100909.6 discloses a kind of domperidone dropping pills, but the domperidone dropping pills prepared according to the disclosed preparation method has a low qualified product rate of roundness rate in industrial production, and the weight difference of pills is also large. It is quite different from the quality index of the dripping pill preparation stipulated in the national drug standard. Such a product seriously affects the accuracy of the dosage in use, and also reduces the pass rate of the product in production, increasing the production cost. Thereby indirectly increasing the cost of medication for patients, thus making its practicability also decrease thereupon

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0024] Adopt the domperidone dropping pill that the present invention prepares, experimental data is as follows:

[0025] Domperidone (domestic trade name Domperidone): 1000g

[0026] Substrates: three mixed substrates as described in the preparation method

[0027] Domperidone: matrix = 1:4;

[0028] According to above-mentioned formula and preparation method made dropping pill, some brief physical and chemical indexes are as follows:

[0029] method one

[0030] Weight per pill: 50mg, difference in pill weight <6%;

[0031] Active ingredient content: 20%

[0032] Rounding rate: >92%

[0033] Properties: This product is white granular, odorless;

[0034] Put the whole drop pill into clean water at room temperature and wait for about 6 minutes to dissolve completely.

[0035] Method Two

[0036] The weight of each pill: 50mg, the difference of pill weight is less than 7%;

[0037] Active ingredient content: 20%

[0038] Rounding rate: >93%

[0039] Properties: This ...

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PUM

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Abstract

A dripping pill of domperidone for treating indigestion, nausea, vomiting, etc is prepared from domperidone and matrix.

Description

technical field [0001] The invention relates to a pharmaceutical composition with gastrointestinal prokinetic effect for treating dyspepsia, abdominal distension, belching, nausea and vomiting, in particular to an oral preparation of the pharmaceutical composition prepared from domperidone. Background technique [0002] Domperidone is a gastric motility and antiemetic drug developed by Janson Company in Belgium. It is used to treat functional, organic and infectious nausea, vomiting and non-ulcer dyspepsia. "Guidelines for Product Development" is a product recommended by the relevant state departments to concentrate on R&D and localization. The drug was first launched in Belgium in 1978 and has been successively launched in Germany, Italy, Britain, Japan, France and other countries, and has been widely used in countries all over the world. my country introduced this product in 1986, and Xi'an Janssen Company exclusively imported raw materials to produce preparations and sel...

Claims

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Application Information

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IPC IPC(8): A61K31/454A61K9/20A61P1/14
Inventor 曲韵智徐俊福
Owner 北京博智绿洲医药科技有限公司
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