Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Production method of dexamethasone series product 16,17-bibone intermediate

A technology for dexamethasone series products, applied in the field of dexamethasone series products 16, can solve the problems of severe reaction conditions, serious environmental pollution, unsatisfactory quality of reducing substances, etc.

Inactive Publication Date: 2006-08-30
TIANJIN TIANYAO PHARM CO LTD
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The traditional method for preparing 16,17-double bond intermediates of dexamethasone series products requires three-step chemical reactions, the reaction conditions are severe, and a large amount of flammable, explosive, and dangerous reagents are used. The yield is very low, and the quality of the obtained reduced product is not ideal

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Production method of dexamethasone series product 16,17-bibone intermediate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Using the traditional method for preparing 16,17-double bond intermediates of dexamethasone series products, using dexamethasone intermediate oxides as raw materials, feeding 50kg, through three-step chemical reactions, 37.5kg of reduced products with a content of 87% were obtained.

Embodiment 2

[0020] Take dexamethasone intermediate oxide as raw material, feed 50kg, use ethanol as solvent, and react with chromite reducing agent. After the reaction is completed, the reaction solution is diluted with a large amount of water, filtered, and dried to obtain 39.7kg of the reduced product. 90.5%.

Embodiment 3

[0022] Take dexamethasone intermediate oxide as raw material, feed 50kg, use ethanol as solvent, and react with chromite reducing agent. After the reaction is completed, the reaction solution is diluted with a large amount of water, filtered, and dried to obtain 40.2kg of the reduced product. 91%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a production method of dexamethasone series product 16,17-double-bond intermediate. Said method includes the following steps: using dexamethasone intermediate oxide as raw material, using ethyl alcohol as solvent, using chromous salt reducing agent to make reaction, after the reaction is completed, using water to dilute reaction solution, filtering, drying to obtain reduced product. Said method can greatly raise quality and yield of reduced product.

Description

Technical field: [0001] The invention relates to a production process of dexamethasone series products. In particular, it relates to a production process of 16,17-double bond intermediates of dexamethasone series products. Background technique: [0002] The traditional method for preparing 16,17-double bond intermediates of dexamethasone series products requires three-step chemical reactions, the reaction conditions are severe, and a large amount of flammable, explosive, and dangerous reagents are used. The yield is very low, and the quality of the resulting reduced product is not ideal. Invention content: [0003] The present invention aims at the problems and deficiencies in the prior art, and provides a new dexamethasone series product 16,17-double bond intermediate (reduced product) production process, using the dexamethasone intermediate oxide as a raw material, Reaction with ethanol as solvent and chromite reducing agent: [0004] [0005] After the reactio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07J7/00
Inventor 卢彦昌蒋基平祝翠红
Owner TIANJIN TIANYAO PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com