Use of lychee seed flavonoid and anthraquinone compound in preventing and treating respiratory syncytial virus infectious disease

A technology of polyphenolic compounds and infectious diseases, applied in the field of application of litchi kernel flavonoid polyphenolic compounds in the prevention and treatment of respiratory syncytial virus infectious diseases

Inactive Publication Date: 2006-10-11
GUILIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no safe and effective vaccine against RSV infection, so the research on anti-RSV drugs has become a topic of international medical attention in recent years.

Method used

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  • Use of lychee seed flavonoid and anthraquinone compound in preventing and treating respiratory syncytial virus infectious disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Litchi kernel flavonoids and polyphenols are made into injections of litchi kernel injection, the total content of litchi kernel flavonoids and polyphenols is 100mg / ml, each 2.0ml, clinically used to prevent and treat respiratory syncytial virus Diseases, usage: 2.0ml each time, intramuscular injection, intravenous injection or intravenous drip, 2 times a day, 5 days a course of treatment.

Embodiment 2

[0029] Embodiment 2: Litchi kernel flavonoids and polyphenols are made into litchi kernel tablets, the total content of litchi kernel flavonoids and polyphenols is 100mg / 0.3g / tablet, which is clinically used to prevent and treat diseases caused by respiratory syncytial virus . Usage 2-4 tablets each time, orally, 2-3 times a day, 7 days as a course of treatment.

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PUM

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Abstract

Disclosed is the use of semen litchi flavonoid and polyphenol compounds in preventing and treating diseases caused by respiratory syncytial virus, wherein the semen litchi flavonoid and polyphenol compounds are prepared into any pharmaceutical dosage forms, the medium toxic concentration TC50 of the semen litchi flavonoid and polyphenol compounds to Hep-2 cells is 360.2 mg / ml, as compared by 364.7.3mug / ml, its anti-RSV medium effective concentration IC50 is 66.8mu / ml, as compared by 66.3mug / ml, the medicinal therapeutic index TI=5.4, as compared by 5.5, when the medicinal concentration is higher than 128mug / ml, the suppression rate to RSV cell pathology can reach over 50%, and the amount-effectiveness relevance is evident, i.e. the suppression rate rises with the increase of the medicament concentration.

Description

(1) Technical field: [0001] The invention relates to the application of litchi kernel flavonoids and polyphenols, in particular to the application of litchi kernel flavonoids and polyphenols in preventing and treating respiratory syncytial virus infectious diseases. (two) background technology: [0002] Respiratory syncytial virus (RSV) belongs to the genus Pneumovirus of the family Paramyxoviridae, which is the same genus as parainfluenza pathogens. They are both single-negative-sense RNA viruses and can cause upper and lower respiratory diseases. They are acute lower respiratory tract diseases in infants and young children. Infection with a common pathogen, almost all children under the age of 2 have been infected with RSV [8] . In recent years, RSV infection has been found to be an important virus in the elderly and immunosuppressed adults [9] . There is still no specific and effective treatment for RSV infection. The antiviral drug ribavirin (also known as Ribavirin,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K36/77A61K9/08A61K9/20A61P31/12
Inventor 徐庆罗伟生张奉学苏小建龚受基梁荣感李丽亚韦京辰
Owner GUILIN MEDICAL UNIVERSITY
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