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Composition containing butylbenzene peptide

A technology of butylphthalide and composition, which is applied in the direction of drug combination, medical preparations containing active ingredients, plant raw materials, etc., and can solve the problem of unsatisfactory treatment of cerebral ischemic diseases, etc.

Active Publication Date: 2006-11-01
CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, although the medicines for cerebral ischemic diseases in the domestic and foreign markets have their own characteristics and play certain roles, these drugs are not ideal for the treatment of cerebral ischemic diseases.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1, prepare salvia miltiorrhiza, extract of Dalbergia lanceolata respectively

[0022] Soak 1000g of balsamic burdock with water, carry out steam distillation, collect about 500ml of distillate, refrigerate for 24 hours, separate the oil layer for later use, concentrate the aqueous solution to extract, and obtain the balsamic balsamic extract.

[0023] Add 1000g of Salvia miltiorrhiza to decoct three times, add 8 times the amount of water for the first time, and decoct for 2 hours; add 6 times the amount and 5 times the amount of water for the second and third times, decoct for 1.5 hours each time, combine the decoction, filter, Concentrate the filtrate to 670-760ml; add ethanol to make the alcohol content reach 75%, let stand for 40 hours, filter, recover ethanol from the filtrate, concentrate to 330ml, add ethanol to make the alcohol content reach 85%, let stand for 40 hours, Filtrate, recover ethanol from the filtrate, concentrate to 200-300ml, add 1000-165...

Embodiment 2

[0024] Embodiment 2, preparation contains the soft capsule of butylphthalide, salvia miltiorrhiza extract, balsamic extract

[0025] Take respectively 200 g of the extract of Dalbergia radiata extract and 200 g of extract of Salvia miltiorrhiza in Example 1, add 500 g of soybean oil under stirring, mix well, add 100 g of butylphthalide, continue stirring until all are well mixed to obtain the contents; Shell liquid, compressed soft capsule.

Embodiment 3

[0026] Embodiment 3: preparation contains the soft capsule of butylphthalide, salvia miltiorrhiza extract

[0027] Take 400 g of the salvia miltiorrhiza extract in Example 1, add 600 g of soybean oil under stirring, mix well, add 200 g of butylphthalide, continue stirring until all the contents are mixed evenly; prepare capsule shell liquid, and press soft capsules.

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PUM

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Abstract

A composition for preventing and treating the cerebral ischemia is prepared from butylphenyl phthaleine, the extract of red sage root and the extract of dalbergia wood.

Description

technical field [0001] The present invention relates to the composition of butylphthalide, salvia miltiorrhiza and radix balsamicus, specifically the compound preparation of butylphthalide, salvia miltiorrhiza and extracts of radix balsamicus for preventing and treating cerebral ischemic diseases. Background technique [0002] Through in-depth studies at the level of whole animals, cells and molecular biology, it has been proved that butylphthalide has the following pharmacological activities: reducing the size of cerebral infarction in rats with local cerebral ischemia and improving the loss of neurological function; improving local cerebral blood flow and improving cerebral microcirculation ; anti-thrombosis and anti-platelet aggregation; reduce brain edema in rats with local cerebral ischemia; protect damaged nerve cells; improve energy metabolism exhaustion in mice with global cerebral ischemia; Memory impairment, etc., clinically used to treat acut...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/48A61K31/365A61P9/10
Inventor 刘振涛杨丽英郭文敏申东民李清娟
Owner CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD
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