Injection emulsion containing breviscapinum and preparation method thereof

A technology of scutellarin and emulsion, which is applied in the field of injection emulsion containing scutellarin and its preparation, can solve the problems of scutellarin instability, poor effect of scutellarin, easy deterioration in storage, etc., and achieve bioavailability, Prevention and treatment of cerebrovascular diseases, the effect of simple preparation method

Inactive Publication Date: 2006-12-13
石家庄大为生物技术有限公司
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the clinical application of breviscapine is mainly small injections, but it is found that low doses of breviscapine are not effective, and only large doses of breviscapine can be effective
In clinical application, many small needles need to be sawn open and then poured into normal saline or glucose injection for intravenous infusion, which is not only troublesome to operate, but also more likely to cause secondary pollution
In addition, although the breviscapine freeze-dried preparations that have been on the market have greatly impro...

Method used

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  • Injection emulsion containing breviscapinum and preparation method thereof

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Embodiment Construction

[0035] One, the embodiment of the injection emulsion containing breviscapine (see Table 1):

[0036] Table 1:

[0037]

[0038] Note: (1) The unit of proportioning in the above table is percentage by weight.

[0039] (2) The amount of the freeze-dried excipient is 0.2-0.4 times that of the emulsion, and the amounts of the freeze-dried excipient in Examples 4, 5, and 6 are respectively 0.2, 0.3, and 0.4 times that of the emulsion.

[0040] (3) The freeze-drying excipient is selected from any one of dextran, mannitol, glucose, lactose, sucrose, and trehalose.

[0041] (4) The oil for injection is selected from soybean oil, cottonseed oil, corn oil, oleic acid, fish oil, Schisandra oil, safflower oil, hydrogenated peanut oil, and linoleic acid.

[0042] (5) The emulsifier is selected from any one of soybean phospholipids, egg yolk phospholipids, hydrogenated phospholipids, and polyoxyethylene-polyoxypropylene chimeras.

[0043] (6) Adjust the isotonic agent to glycerin.

...

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Abstract

The invention relates to an emulsion injection containing Breviscapine and its preparing process, which is prepared from the following raw materials (by weight portion): Breviscapine 0.01-0.04%, oil for injection 5-30%, emulsifying agent 1-5%, isotonic agent 2-10%, stabilizer 0.1-8% and balancing water for injection. The preparation process comprises the steps of proportioning, making oily phase mixture, making initial milk, emulsifying and sterilizing.

Description

technical field [0001] The invention relates to a medicine for preventing and treating ischemic and hemorrhagic cerebrovascular sequelae, and treating cardiovascular and cerebrovascular diseases, specifically an injection emulsion containing breviscapine; the invention also relates to the production of the injection emulsion containing breviscapine method. technical background [0002] Breviscapus is a total flavonoid extracted from Erigeron breviscapus (Vant.) Hand-Mazz plant of Compositae, more than 90% of which is scutellarin, which can expand microvessels, improve microcirculation, Improve myocardial function and blood supply to the heart and brain, reduce blood viscosity, inhibit platelet aggregation, prevent thrombosis and thrombolysis, and lower blood lipids. At present, the clinical application of breviscapine is mainly small injections, but it is found in clinical application that low doses of breviscapine are not effective, and only large doses of breviscapine can...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/107A61P9/10A61P7/02A61P3/06
Inventor 高春平
Owner 石家庄大为生物技术有限公司
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