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Medicine having anti-bacterial anti-viral functions and formulation thereof

A technology of antiviral effect and pharmaceutical preparation, applied in the field of medicine, can solve the problems of non-detection, acid and alkali resistance, etc., and achieve the effects of small dosage, tight packaging, and protection of the therapeutic activity of the drug

Inactive Publication Date: 2006-12-20
SHANGHAI YOUSEEN NEW MEDICINE EXPLOITION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, forsythiaol is afraid of high temperature and is not resistant to acid and alkali. Therefore, only caffeic acid is detected in the patent medicines containing forsythia sold on the market, such as Yinqiaojiedu pills and Yinqiaojiedu tablets. The antibacterial active ingredients are often not detected, so that forsythia cannot maximize the antibacterial and antiviral effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: (preparation of extract)

[0040] Distill and extract Forsythia 3 times with 8 times of water, 1.5 hours each time, collect volatile oil for later use; combine the extracts, filter, concentrate under reduced pressure, add 0.05 times the amount of diatomite of Forsythia, mix well, and let it dry Dry. Take 70% ethanol that is 3 times the amount of Forsythia raw material, ultrasonically extract the dried diatomaceous earth, and extract 4 times for 30 minutes each time; combine the alcohol extracts, concentrate until the content of the medicinal material is 0.5g / ml, and open the large hole Resin, the weight of the resin is 3 times the weight of the raw material of forsythia, and the control flow rate is 1000-3000L / m2 h. After the completion of the process, wash away the residual impurities in the resin column with water 10 times the weight of the raw material of forsythia, then desorb with 80-90% ethanol 5 times the weight of the resin, collect the ethanol so...

Embodiment 2

[0041] Embodiment 2: (preparation of extract)

[0042] Extract forsythia fruit 3 times with 8 times of water distillation, 2.5 hours each time, collect volatile oil for later use; combine extracts, filter, concentrate under reduced pressure, add diatomaceous earth with 0.08 times the amount of forsythia fruit, mix well, and let it dry Dry. Take 80% ethanol that is 4 times the amount of Forsythia raw material, ultrasonically extract the dried diatomaceous earth, and extract 4 times for 30 minutes each time; combine the alcohol extracts, concentrate until the content of the medicinal material is 0.5g / ml, and open the large hole Resin, the weight of the resin is 5 times the weight of the raw material of forsythia, and the control flow rate is 1000-3000L / m2 h. After the completion of the process, wash away the residual impurities in the resin column with water 20 times the weight of the forsythia fruit, then desorb with 90% ethanol 10 times the weight of the resin, collect the et...

Embodiment 3

[0043] Embodiment 3: (preparation of extract)

[0044] Distill and extract forsythia leaves 3 times with 6 times of water, 2 hours each time, collect volatile oil for later use; combine the extracts, filter, concentrate under reduced pressure, add diatomaceous earth with 0.03 times the amount of forsythia leaves, mix well, and let it dry Dry. Take 80% ethanol that is 4 times the amount of Forsythia raw material, ultrasonically extract the dried diatomaceous earth, and extract 4 times for 30 minutes each time; combine the alcohol extracts, concentrate until the content of the medicinal material is 0.5g / ml, and open the large hole Resin, the weight of the resin is 4 times the weight of the forsythia raw material, and the flow rate is controlled to be 1000-3000L / m2 h. After finishing the process, wash away the residual impurities in the resin column with 15 times the weight of forsythia leaves, then desorb with 90% ethanol that is 10 times the weight of the resin, collect the et...

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PUM

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Abstract

The invention relates to a medicament having antibiotic and antivirus actions comprising weeping forsythia extract, wherein the active constituents are forsythol and weeping forsythia oil. The composition can be prepared into any of the pharmacologically acceptable dosage forms.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a medicine with antibacterial and antiviral effects prepared from the extract of the traditional Chinese medicine Forsythia japonicus and its preparation. technical background [0002] Forsythia (Fructus Forsythiae) is a plant of the genus Forsythia in the family Oleaceae. In traditional Chinese prescriptions, the fruit of forsythia is often used as medicine, and it is used together with other heat-clearing and detoxifying drugs to play a role in clearing away heat and detoxifying, dispelling stagnation and reducing swelling. At present, scholars at home and abroad have conducted many researches on the chemical constituents and pharmacology of Forsythia, among which the research on antibacterial and antiviral activities is particularly significant. Forsythol (forsythol) extracted from Forsythia has a strong antibacterial effect, and its main component, forsythiaside, has a str...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61K9/20A61K9/48A61P11/00A61P31/12A61K131/00
Inventor 玄振玉黄孝春林君于莉
Owner SHANGHAI YOUSEEN NEW MEDICINE EXPLOITION