Method for modifying artificial implanter by covalent cross-linking gel

A technology of covalent cross-linking and implants, which is applied in the field of biomedical materials, can solve the problems of the influence of the material body structure, complex operation process, and expensive equipment, so as to improve anticoagulant performance, simple process, and reduce viscosity. echo the effect of aggregation

Inactive Publication Date: 2006-12-27
HARBIN INST OF TECH
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Benefits of technology

This technology allows for better control over the properties or behavior of medical device coatings made from synthetic substances without damaging them during manufacturing processes. By applying this technique it becomes possible to create more durable coatings than previously used methods like plasma treatment. Additionally, there are technical benefits such as improved bioavailability, reduced immune responses against therapeutic agents, enhanced wound healing capabilities, increased stability under physiological environments, lower cost compared to current techniques, etc., making these technologies useful tools for various applications involving medicine and other fields where they could be applied safely and effectively.

Problems solved by technology

This patents discusses various technical problem addressed in this patent: improving the quality and efficiency of medical devices made from synthetic resins like those described above while maintaining their strength against corrosion and enzymatic reactions. Current treatments involve adding metal salts onto the surfaces of the device, increasing resistance towards proteases and causing inflammatory responses. There is currently no effective solution for achieving both stable attachment and efficient functioning of healing substances within the device itself.

Method used

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  • Method for modifying artificial implanter by covalent cross-linking gel
  • Method for modifying artificial implanter by covalent cross-linking gel
  • Method for modifying artificial implanter by covalent cross-linking gel

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specific Embodiment approach 1

[0018] Specific embodiment one: this embodiment is achieved in this way: a, the artificial implant body is soaked in the organic solvent ultrasonic cleaning, dry; b, the concentration is the polyanion of 0.01-100 mg / ml ml of polycations are alternately deposited on the surface of the artificial implant by electrostatic attraction, or directly deposit a cationic surfactant with a concentration of 0.01-100 mg / ml on the surface of the artificial implant instead of polyanions and polycations, The adsorption time is 0.1-300 minutes; c. Prepare a polymer solution containing carboxylic acid groups at a concentration of 0.01-100mg / ml or a mixed solution with biologically active substances, and apply it to the artificial implant On the surface, add polyamine with a concentration of 0.01-100M and [1-ethyl-3-(3-dimethylamino-propyl)]-carbodiimide (EDC) with a concentration of 0.01-100M for crosslinking, and let stand for 0.1 to 300 hours; d. Use CaCl 2 (or BaCl 2 ) and other inorganic ...

specific Embodiment approach 2

[0030] Specific implementation mode two: this implementation mode is realized in this way:

[0031] (1) Artificial blood vessel pretreatment: ultrasonically clean the artificial blood vessel in absolute ethanol for 1-300 minutes, and dry at 10-150°C for 0.1-24 hours.

[0032] (2) The artificial blood vessel is perfused with 0.01-30 wt% perfluorosulfonic acid solution, soaked for 1-300 minutes, and dried.

[0033] (3) Perfuse the dried artificial blood vessel with 0.01-100 mg / ml chitosan solution, soak for 1-300 minutes, and wash with water.

[0034] (4) Repeat steps (2) and (3) until the desired number of (perfluorosulfonic acid / chitosan) bilayers is reached.

[0035] (5) Prepare a mixed solution of heparin and sodium alginate, add an appropriate amount of ethylenediamine and [1-ethyl-3-(3-dimethylamino-propyl)]-carbodiimide (EDC), mix well, and infuse the modified perfluorosulfonic acid / chitosan artificial blood vessel, let stand for 0.1 to 300 hours.

[0036] (6) Use Ca...

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Abstract

Disclosed is a method for surface modification of an artificial implant with covalent cross-linked gel to make same of good blood compatibility and histocompatibility, comprising a.alternately depositing polyanions and polycations on artificial implant surface via electrostatic attraction; b.preparing carboxyl acid group polymer solution or mixing solution thereof with biologically active substance, coating said solution on artificial implant surface, adding appropriate amount of polyamine and cross-linking with [1-ethyl-3-(3-dimethylamino-propyl)]-carbodiimide(EDC); c.rinsing the artificial implant with a mixing solution of CaCl2(or BaCl2) and other inorganic salts, washing same with water, and drying same.

Description

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Claims

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Application Information

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Owner HARBIN INST OF TECH
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