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Developing method for Chinese medicine compound secondary new medicine

A technology for compound prescriptions and new drugs, applied in the field of secondary new drug development, can solve the problems of not being able to form a research path, not much depth, etc., and achieve the effects of reducing development costs and risks, avoiding complicated processes, and shortening the development cycle

Inactive Publication Date: 2007-01-24
TSINGHUA UNIV
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AI Technical Summary

Problems solved by technology

2. The modern scientific research done according to the theory of traditional Chinese medicine, the research in this area has a wide range, but not much depth
However, due to the influence of various constraints such as the expression of the material basis, the interpretation of the mechanism of action, and the modern interpretation of the law of compatibility, the research on compound prescriptions has not been able to form a complete and reasonable research approach for a long time.

Method used

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  • Developing method for Chinese medicine compound secondary new medicine
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  • Developing method for Chinese medicine compound secondary new medicine

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Embodiment Construction

[0050] Below in conjunction with the accompanying drawings, and taking the secondary new drug development of Qingkailing injection as an example, the method of the present invention is described in detail, but the scope of protection of the present invention should not be limited to this embodiment. According to the method of the present invention, each A traditional Chinese medicine compound for the development of secondary new drugs.

[0051] 1. Analysis of the basic formula of Qingkailing Injection

[0052] 1. Qingkailing Injection is derived from the ancient prescription Angong Niuhuang Pills

[0053] Qingkailing Injection is a new traditional Chinese medicine preparation developed by Beijing College of Traditional Chinese Medicine (now Beijing University of Traditional Chinese Medicine) in the 1970s. Angong Niuhuang Pill is a traditional Chinese patent medicine, which has the functions of clearing heat and detoxifying, calming the nerves, avoiding filth and rejuvenating ...

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Abstract

The present invention is secondary development process of compound Chinese medicine. The secondary development process includes the following steps: 1. selecting old recipe or proved recipe in use for long term, performing the medicine component analysis, recognizing the compound Chinese medicine recipe on the Chinese medicinal material level, and merging and decreasing medicine materials; 2. performing the analysis of medicine material components chemically and with fingerprints, and performing component identification and classifying; 3. proposing new recipe; 4. performing chemical component and fingerprint analysis of the medicine materials in new recipe, and determining the new production process; and 5. designing recipe proportioning by means of homogeneous design scheme, performing relevant pharmacodynaical and pharmacological experiments, and comparing the experiment results to determine the optimal recipe.

Description

technical field [0001] The invention relates to a method for developing a new traditional Chinese medicine, in particular to a method for secondary new drug development through research on the compatibility of traditional Chinese medicines under the guidance of modern Chinese medicine theories. Background technique [0002] Traditional Chinese medicine compound is the essence of traditional Chinese medicine. Suikan natural medicine extracts are widely used in the alternative treatment of disease drug treatment. Influenced by holistic medication and macroscopic treatment concepts, traditional Chinese medicine treatment cannot be well integrated into the modern drug treatment system, nor can it fully explain the exact material basis of drug action from the perspective of components, which interferes with the development and internationalization of traditional Chinese medicine. , hindered the further development of traditional Chinese medicine. Since Chinese materia medica is ...

Claims

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Application Information

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IPC IPC(8): A61K36/00G01N30/02G01N33/15
Inventor 罗国安王义明严诗凯曹进梁琼麟
Owner TSINGHUA UNIV
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