Cardiac and cerebral vascular disease treating pharmaceutical composition

A technology of cardiovascular and cerebrovascular diseases and compositions, which is applied in the direction of cardiovascular system diseases, drug combinations, active ingredients of hydroxyl compounds, etc., can solve problems such as inability to take care of oneself, relatives and social burdens, and achieve quality control, easy industrialization, multi-benefit effect

Inactive Publication Date: 2007-02-28
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The percentage of deaths due to cardiovascular and cerebrovascular diseases in the total death population in my country has risen from 12.07% in 1957 to 42.6% in 2001, and 2 million people died of cardiovascular and cerebrovascular diseases every year, and some patients survived despite rescue. , but most of them are disabled and unable to take care of themselves, causing serious burden to relatives and society

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Preparation of tanshinone extract: Take the pulverized salvia miltiorrhiza and put it into CO 2 The extraction kettle in the extraction equipment, when all parts of the system reach the set temperature, the pressure of the extraction kettle is increased to the set pressure. Add 95% ethanol solution to the system according to the set flow rate, and CO 2 After mixing, the dynamic extraction is circulated in the whole system; the extraction conditions are extraction pressure 20MPa, extraction temperature 45°C, separation temperature 35°C, and ethanol flow rate 1.0mL / min; after the extraction is completed, the extract is released, concentrated, and vacuum-dried to obtain Tanshinone extract, its total tanshinone content is 64%. The extracted medicinal material residue is used for future use.

[0090] Preparation of the total phenolic acid extract of Salvia miltiorrhiza: take the medicinal material residue after extracting tanshinone, and obtain it according to the preparati...

Embodiment 2

[0095] Preparation of tanshinone extract: take Danshen decoction pieces or pulverized Danshen, add 95% ethanol to soak for 2 hours, then reflux extraction at 75°C for 3 times, each time the amount of solvent is 5 times the weight of the crude drug, and the extraction time is 60 minutes, 30 minutes and 30 minutes; combine the extracts, and concentrate the extracts under reduced pressure below 50°C to 1 / 40 of the original volume to obtain a concentrate; add 3 times the volume of water to the concentrate, let it stand for 12 hours, and filter; Dry below 50°C to obtain tanshinone extract, the total tanshinone content is 61%. The extracted medicinal material residue is used for future use.

[0096] Preparation of the total phenolic acid extract of Salvia miltiorrhiza: take the medicinal material residue after extracting tanshinone, and obtain it according to the preparation method in Example 1 of Chinese patent application CN1384090A. The total phenolic acid content of the salvia m...

Embodiment 3

[0101] Preparation of tanshinone extract: Take the pulverized salvia miltiorrhiza and put it into CO 2 The extraction kettle in the extraction equipment, when all parts of the system reach the set temperature, the pressure of the extraction kettle is increased to the set pressure. Add 90% ethanol solution to the system according to the set flow rate, and CO 2 After mixing, the dynamic extraction is circulated in the whole system; the extraction conditions are extraction pressure 250MPa, extraction temperature 45°C, separation temperature 35°C, and ethanol flow rate 0.8mL / min; after the extraction is completed, the extract is released, concentrated, and vacuum-dried to obtain Tanshinone extract, its total tanshinone content is 59%. The extracted medicinal material residue is used for future use.

[0102] Preparation of the total phenolic acid extract of Salvia miltiorrhiza: take the medicinal material residue after extracting tanshinone, and obtain it according to the preparat...

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PUM

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Abstract

The invention discloses a Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases, which comprises 35.0-75% of astragalus root saponin extract containing total saponins 70-98%, 0.5-5.0% of tanshinone extract containing tanshinone 55-85%, 15.0-55.0% of total savianolic acid extract containing total savianolic acid 70-98%, 2.5-15.0% of pseudo-ginseng leaf glycosides extract containing total saponins 70-98%, and natural borneol or rosewood oil 2.5-15.0%. The composition has evident functions in resisting cerebral ischemia and myocardial ischemia, the curative effect is better than the application of single extract of tanshinone, total savianolic acid or pseudo-ginseng leaf glycosides, thus providing a more effective and more convenient Chinese medicinal composition and preparation clinically.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] According to my country's epidemiological survey, the incidence and mortality of cardiovascular and cerebrovascular diseases have been on the rise in the past 50 years, whether in rural areas or cities. In the 1950s and 1960s, cardiovascular disease and cerebrovascular disease ranked fifth and sixth among the causes of death in my country, and rose to second and third respectively after 1975. Cardiovascular and cerebrovascular diseases accounted for the first place among all causes of death. The percentage of deaths due to cardiovascular and cerebrovascular diseases in the total death population in my country has risen from 12.07% in 1957 to 42.6% in 2001, and 2 million people died of cardiovascular and cerebrovascular diseases every year, and some patients survived ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/14A61K9/20A61P9/00A61K31/045
Inventor 叶正良李旭张文生魏峰李德坤
Owner TIANJIN TASLY PHARMA CO LTD
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