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Application of Dendrobium nobile in the preparing process of bone disease treating medicine

A technology for treating bone diseases and fractures, which is applied in bone diseases, drug combinations, and pharmaceutical formulations, etc.

Inactive Publication Date: 2007-02-28
NANKAI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there have been no literature reports on the use of single-flavored natural medicine Dendrobium powder, Dendrobium water extract, and Dendrobium polysaccharide components for the treatment and / or prevention of bone diseases. , Dendrobium water extract, Dendrobium polysaccharide components, etc. have shown extremely high pharmacological activity in the treatment of bone diseases

Method used

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  • Application of Dendrobium nobile in the preparing process of bone disease treating medicine
  • Application of Dendrobium nobile in the preparing process of bone disease treating medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1: the preparation of dendrobium water extract

[0049] Take 200g of dendrobium powder and boil it with 2500ml of water for about 1 hour. After cooling to room temperature, the extract is centrifuged, the residue after extraction is boiled with water, cooled and then centrifuged, and the two supernatants are combined to obtain a dendrobium water extract, which is then concentrated. The water extract is dried for later use.

Embodiment 2

[0050] Embodiment 2: the extraction of dendrobium polysaccharide

[0051] Take 220 grams of dendrobium powder, add petroleum ether 1000ml, reflux extraction for 1 hour, filter, and evaporate the solvent from the filter residue. Reflux extraction with 1000ml of 80% ethanol for 1 hour, filter, put the filter residue in a round bottom flask, add 3000ml of distilled water, extract under reflux for 1 hour, filter under heat, concentrate under reduced pressure to 300ml, add 0.1% activated carbon for decolorization, filter, add 95% ethanol Make the solution containing 80% alcohol, let stand overnight, and filter. The polysaccharide is dried for later use.

Embodiment 3

[0053] Take 50.0g of dendrobium water extract, 30.0g of medicinal starch, 30.0g of dextrin, and an appropriate amount of 50% ethanol, fully stir and mix the above raw materials to make granules, dry at 60-70°C for 2-4 hours, and make 100 tablets. Each tablet contains 0.5g of dendrobium water extract.

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Abstract

The invention relates to the use of Dendrobium nobile in preparing medicament for the treatment and / or prevention of bone diseases. Tests result shows that Dendrobium nobile or its effective extract composition can specifically promotes the new bone formation, thus can be used for preventing and treating osteoporosis and various bone fractures.

Description

technical field [0001] The invention belongs to the technical field of natural medicines, and relates to the pharmaceutical development and utilization of dendrobium, more precisely, the application of dendrobium or its extracts in the preparation of medicines for treating bone diseases. Background technique [0002] Bone tissue is a hard connective tissue mainly composed of three types of cells (osteoblasts, osteocytes and osteoclasts) and an extracellular matrix. These cells secrete collagen fibers, non-collagen fibril proteins and regulatory factors. The extracellular matrix is ​​mainly composed of calcium and phosphate. The growth, development, metabolism and aging of bone tissue manifest as an increase or decrease in bone mass. The bone is in a dynamic balance through bone resorption and bone remodeling. This homeostasis is required both for the renewal of defective bone due to normal aging and trauma, and for maintaining good bone integrity and weight-bearing capaci...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61P19/10A61K135/00
Inventor 朱天慧
Owner NANKAI UNIV
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